دورية أكاديمية
Maintenance of mitochondrial homeostasis for Alzheimer's disease: Strategies and challenges
| العنوان: | Maintenance of mitochondrial homeostasis for Alzheimer's disease: Strategies and challenges |
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| المؤلفون: | Ying Han, Daozhou Liu, Ying Cheng, Qifeng Ji, Miao Liu, Bangle Zhang, Siyuan Zhou |
| المصدر: | Redox Biology, Vol 63, Iss , Pp 102734- (2023) |
| بيانات النشر: | Elsevier, 2023. |
| سنة النشر: | 2023 |
| المجموعة: | LCC:Medicine (General) LCC:Biology (General) |
| مصطلحات موضوعية: | Alzheimer's disease, Oxidative phosphorylation, Mitochondrial dynamics, Mitochondrial quality control, Mitochondrial targeting, Medicine (General), R5-920, Biology (General), QH301-705.5 |
| الوصف: | Alzheimer's disease (AD) is one of the most common neurodegenerative diseases, and its early onset is closely related to mitochondrial energy metabolism. The brain is only 2% of body weight, but consumes 20% of total energy needs. Mitochondria are responsible for providing energy in cells, and maintaining their homeostasis ensures an adequate supply of energy to the brain. Mitochondrial homeostasis is constituted by mitochondrial quantity and quality control, which is dynamically regulated by mitochondrial energy metabolism, mitochondrial dynamics and mitochondrial quality control. Impaired energy metabolism of brain cells occurs early in AD, and maintaining mitochondrial homeostasis is a promising therapeutic target in the future. We summarized the mechanism of mitochondrial homeostasis in AD, its influence on the pathogenesis of early AD, strategies for maintaining mitochondrial homeostasis, and mitochondrial targeting strategies. This review concludes with the authors' opinions on future research and development for mitochondrial homeostasis of early AD. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2213-2317 |
| Relation: | http://www.sciencedirect.com/science/article/pii/S2213231723001350; https://doaj.org/toc/2213-2317 |
| DOI: | 10.1016/j.redox.2023.102734 |
| URL الوصول: | https://doaj.org/article/71abc15962fb48ed966961acfc2930ec |
| رقم الأكسشن: | edsdoj.71abc15962fb48ed966961acfc2930ec |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 22132317 |
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| DOI: | 10.1016/j.redox.2023.102734 |