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Antartin, a Cytotoxic Zizaane-Type Sesquiterpenoid from a Streptomyces sp. Isolated from an Antarctic Marine Sediment

التفاصيل البيبلوغرافية
العنوان: Antartin, a Cytotoxic Zizaane-Type Sesquiterpenoid from a Streptomyces sp. Isolated from an Antarctic Marine Sediment
المؤلفون: Dayoung Kim, Eun Ju Lee, Jihye Lee, Alain S. Leutou, Yern-Hyerk Shin, Bomi Choi, Ji Sun Hwang, Dongyup Hahn, Hyukjae Choi, Jungwook Chin, Sung Jin Cho, Yong Deog Hong, Jaeyoung Ko, Chi Nam Seong, Katherine N. Maloney, Dong-Chan Oh, Inho Yang, Hayoung Hwang, Sang-Jip Nam
المصدر: Marine Drugs, Vol 16, Iss 4, p 130 (2018)
بيانات النشر: MDPI AG, 2018.
سنة النشر: 2018
المجموعة: LCC:Biology (General)
مصطلحات موضوعية: Streptomyces sp., cold water natural product, marine natural product, zizaane-type sesquiterpenoid, Biology (General), QH301-705.5
الوصف: Antartin (1), a new zizaane-type sesquiterpene, was isolated from Streptomyces sp. SCO736. The chemical structure of 1 was assigned from the interpretation of 1D and 2D NMR in addition to mass spectrometric data. The relative stereochemistry of 1 was determined by analysis of NOE data, while the absolute stereochemistry was decided based on a comparison of experimental and calculated electronic circular dichroism (ECD) spectra. Antartin (1) showed cytotoxicity against A549, H1299, and U87 cancer cell lines by causing cell cycle arrest at the G1 phase.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 1660-3397
Relation: http://www.mdpi.com/1660-3397/16/4/130; https://doaj.org/toc/1660-3397
DOI: 10.3390/md16040130
URL الوصول: https://doaj.org/article/72b21dfdf2b14bcea07d24dd6575ff67
رقم الأكسشن: edsdoj.72b21dfdf2b14bcea07d24dd6575ff67
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:16603397
DOI:10.3390/md16040130