دورية أكاديمية

Design and Fabrication of a Fully-Integrated, Miniaturised Fluidic System for the Analysis of Enzyme Kinetics

التفاصيل البيبلوغرافية
العنوان: Design and Fabrication of a Fully-Integrated, Miniaturised Fluidic System for the Analysis of Enzyme Kinetics
المؤلفون: Andreas Tsiamis, Anthony Buchoux, Stephen T. Mahon, Anthony J. Walton, Stewart Smith, David J. Clarke, Adam A. Stokes
المصدر: Micromachines, Vol 14, Iss 3, p 537 (2023)
بيانات النشر: MDPI AG, 2023.
سنة النشر: 2023
المجموعة: LCC:Mechanical engineering and machinery
مصطلحات موضوعية: sensors, fluidics, integration, lab-on-a-chip, integrated devices, miniaturised total analysis system, Mechanical engineering and machinery, TJ1-1570
الوصف: The lab-on-a-chip concept, enabled by microfluidic technology, promises the integration of multiple discrete laboratory techniques into a miniaturised system. Research into microfluidics has generally focused on the development of individual elements of the total system (often with relatively limited functionality), without full consideration for integration into a complete fully optimised and miniaturised system. Typically, the operation of many of the reported lab-on-a-chip devices is dependent on the support of a laboratory framework. In this paper, a demonstrator platform for routine laboratory analysis is designed and built, which fully integrates a number of technologies into a single device with multiple domains such as fluidics, electronics, pneumatics, hydraulics, and photonics. This facilitates the delivery of breakthroughs in research, by incorporating all physical requirements into a single device. To highlight this proposed approach, this demonstrator microsystem acts as a fully integrated biochemical assay reaction system. The resulting design determines enzyme kinetics in an automated process and combines reservoirs, three-dimensional fluidic channels, optical sensing, and electronics in a low-cost, low-power and portable package.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 2072-666X
Relation: https://www.mdpi.com/2072-666X/14/3/537; https://doaj.org/toc/2072-666X
DOI: 10.3390/mi14030537
URL الوصول: https://doaj.org/article/a72c7c4011044c4d8596c3971b18e8e1
رقم الأكسشن: edsdoj.72c7c4011044c4d8596c3971b18e8e1
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:2072666X
DOI:10.3390/mi14030537