دورية أكاديمية
Inflammatory gut as a pathologic and therapeutic target in Parkinson’s disease
| العنوان: | Inflammatory gut as a pathologic and therapeutic target in Parkinson’s disease |
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| المؤلفون: | Jea-Young Lee, Zhen-Jie Wang, Alexa Moscatello, Chase Kingsbury, Blaise Cozene, Jeffrey Farooq, Madeline Saft, Nadia Sadanandan, Bella Gonzales-Portillo, Henry Zhang, Felipe Esparza Salazar, Alma Rosa Lezama Toledo, Germán Rivera Monroy, Reed Berlet, Cyndy D. Sanberg, Paul R. Sanberg, Cesario V. Borlongan |
| المصدر: | Cell Death Discovery, Vol 8, Iss 1, Pp 1-10 (2022) |
| بيانات النشر: | Nature Publishing Group, 2022. |
| سنة النشر: | 2022 |
| المجموعة: | LCC:Neoplasms. Tumors. Oncology. Including cancer and carcinogens LCC:Cytology |
| مصطلحات موضوعية: | Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282, Cytology, QH573-671 |
| الوصف: | Gut-Brain Axis as a PD Pathologic Source and Therapeutic Target. The PD murine model of α-synuclein overexpression at around 8 weeks of age manifests gut dysbiosis, characterized by inflammation-specific microbiota and cytokines, which can trigger brain neurodegeneration, especially dopaminergic depletion reminiscent of PD pathology. Targeting the dysbiotic gut via intravenous hUCB stem cell transplantation can render gut homeostasis and sequester peripheral as well as central inflammation, leading to brain repair and amelioration of PD behavioral and histological deficits. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2058-7716 |
| Relation: | https://doaj.org/toc/2058-7716 |
| DOI: | 10.1038/s41420-022-01175-2 |
| URL الوصول: | https://doaj.org/article/d730f1393411479c90a69d8a58f04dc4 |
| رقم الأكسشن: | edsdoj.730f1393411479c90a69d8a58f04dc4 |
| قاعدة البيانات: | Directory of Open Access Journals |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 20587716 |
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| DOI: | 10.1038/s41420-022-01175-2 |