دورية أكاديمية
Towards Clinical Implementation of Adeno-Associated Virus (AAV) Vectors for Cancer Gene Therapy: Current Status and Future Perspectives
العنوان: | Towards Clinical Implementation of Adeno-Associated Virus (AAV) Vectors for Cancer Gene Therapy: Current Status and Future Perspectives |
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المؤلفون: | Ulrich T. Hacker, Martin Bentler, Dorota Kaniowska, Michael Morgan, Hildegard Büning |
المصدر: | Cancers, Vol 12, Iss 7, p 1889 (2020) |
بيانات النشر: | MDPI AG, 2020. |
سنة النشر: | 2020 |
المجموعة: | LCC:Neoplasms. Tumors. Oncology. Including cancer and carcinogens |
مصطلحات موضوعية: | adeno-associated virus (AAV) vectors, transductional targeting, transcriptional targeting, hallmarks of cancer, apoptosis, tumor angiogenesis, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282 |
الوصف: | Adeno-associated virus (AAV) vectors have gained tremendous attention as in vivo delivery systems in gene therapy for inherited monogenetic diseases. First market approvals, excellent safety data, availability of large-scale production protocols, and the possibility to tailor the vector towards optimized and cell-type specific gene transfer offers to move from (ultra) rare to common diseases. Cancer, a major health burden for which novel therapeutic options are urgently needed, represents such a target. We here provide an up-to-date overview of the strategies which are currently developed for the use of AAV vectors in cancer gene therapy and discuss the perspectives for the future translation of these pre-clinical approaches into the clinic. |
نوع الوثيقة: | article |
وصف الملف: | electronic resource |
اللغة: | English |
تدمد: | 12071889 2072-6694 |
Relation: | https://www.mdpi.com/2072-6694/12/7/1889; https://doaj.org/toc/2072-6694 |
DOI: | 10.3390/cancers12071889 |
URL الوصول: | https://doaj.org/article/732ffa6340da4abebe72e3708e0c1edc |
رقم الأكسشن: | edsdoj.732ffa6340da4abebe72e3708e0c1edc |
قاعدة البيانات: | Directory of Open Access Journals |
تدمد: | 12071889 20726694 |
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DOI: | 10.3390/cancers12071889 |