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Towards Clinical Implementation of Adeno-Associated Virus (AAV) Vectors for Cancer Gene Therapy: Current Status and Future Perspectives

التفاصيل البيبلوغرافية
العنوان: Towards Clinical Implementation of Adeno-Associated Virus (AAV) Vectors for Cancer Gene Therapy: Current Status and Future Perspectives
المؤلفون: Ulrich T. Hacker, Martin Bentler, Dorota Kaniowska, Michael Morgan, Hildegard Büning
المصدر: Cancers, Vol 12, Iss 7, p 1889 (2020)
بيانات النشر: MDPI AG, 2020.
سنة النشر: 2020
المجموعة: LCC:Neoplasms. Tumors. Oncology. Including cancer and carcinogens
مصطلحات موضوعية: adeno-associated virus (AAV) vectors, transductional targeting, transcriptional targeting, hallmarks of cancer, apoptosis, tumor angiogenesis, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
الوصف: Adeno-associated virus (AAV) vectors have gained tremendous attention as in vivo delivery systems in gene therapy for inherited monogenetic diseases. First market approvals, excellent safety data, availability of large-scale production protocols, and the possibility to tailor the vector towards optimized and cell-type specific gene transfer offers to move from (ultra) rare to common diseases. Cancer, a major health burden for which novel therapeutic options are urgently needed, represents such a target. We here provide an up-to-date overview of the strategies which are currently developed for the use of AAV vectors in cancer gene therapy and discuss the perspectives for the future translation of these pre-clinical approaches into the clinic.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 12071889
2072-6694
Relation: https://www.mdpi.com/2072-6694/12/7/1889; https://doaj.org/toc/2072-6694
DOI: 10.3390/cancers12071889
URL الوصول: https://doaj.org/article/732ffa6340da4abebe72e3708e0c1edc
رقم الأكسشن: edsdoj.732ffa6340da4abebe72e3708e0c1edc
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:12071889
20726694
DOI:10.3390/cancers12071889