دورية أكاديمية
Pathway-targeting gene matrix for Drosophila gene set enrichment analysis
| العنوان: | Pathway-targeting gene matrix for Drosophila gene set enrichment analysis |
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| المؤلفون: | Jack Cheng, Lee-Fen Hsu, Ying-Hsu Juan, Hsin-Ping Liu, Wei-Yong Lin |
| المصدر: | PLoS ONE, Vol 16, Iss 10 (2021) |
| بيانات النشر: | Public Library of Science (PLoS), 2021. |
| سنة النشر: | 2021 |
| المجموعة: | LCC:Medicine LCC:Science |
| مصطلحات موضوعية: | Medicine, Science |
| الوصف: | Gene Set Enrichment Analysis (GSEA) is a powerful algorithm to determine biased pathways between groups based on expression profiling. However, for fruit fly, a popular animal model, gene matrixes for GSEA are unavailable. This study provides the pathway-targeting gene matrixes based on Reactome and KEGG database for fruit fly. An expression profiling containing neurons or glia of fruit fly was used to validate the feasibility of the generated gene matrixes. We validated the gene matrixes and identified characteristic neuronal and glial pathways, including mRNA splicing and endocytosis. In conclusion, we generated and validated the feasibility of Reactome and KEGG gene matrix files, which may benefit future profiling studies using Drosophila. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1932-6203 |
| Relation: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8553153/?tool=EBI; https://doaj.org/toc/1932-6203 |
| URL الوصول: | https://doaj.org/article/733dcd8cdd1b4f8181bda0cfdeeb0b9f |
| رقم الأكسشن: | edsdoj.733dcd8cdd1b4f8181bda0cfdeeb0b9f |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 19326203 |
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