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Initiating TrkB/Akt Signaling Cascade Preserves Blood–Brain Barrier after Subarachnoid Hemorrhage in Rats

التفاصيل البيبلوغرافية
العنوان: Initiating TrkB/Akt Signaling Cascade Preserves Blood–Brain Barrier after Subarachnoid Hemorrhage in Rats
المؤلفون: Xiangqian Qi, Juan Liu, Jiejin Wu, Yunke Bi, Cong Han, Guiyun Zhang, Meiqing Lou, Jianfei Lu, Junjia Tang
المصدر: Cell Transplantation, Vol 28 (2019)
بيانات النشر: SAGE Publishing, 2019.
سنة النشر: 2019
المجموعة: LCC:Medicine
مصطلحات موضوعية: Medicine
الوصف: The integrity of the blood–brain barrier (BBB) plays a vital role in affecting the prognosis of subarachnoid hemorrhage (SAH). This study aimed to investigate activation of the Tropomyosin-related kinase receptor B (TrkB) and its downstream signaling pathway on preserving BBB breakdown after experimental SAH. An endovascular perforation SAH model was applied. N-[2-(5-hydroxy-1H-indol-3-yl) ethyl]-2- oxopiperidine-3-carboxamide (HIOC), the derivative of N-acetyl serotonin (NAS), was intracerebroventricularly administered 3 h after SAH induction. The neurologic scores and brain water content were evaluated in an outcome study. Western blot and immunofluorescence staining were used to investigate the mechanism. The results indicated that HIOC activated the TrkB/Akt pathway, increased the tight junction expression, improved neurologic deficits, and ameliorated brain edema after SAH. Thus, we conclude that initiating the TrkB/Akt signaling cascade preserves BBB breakdown after experimental SAH in rats.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 0963-6897
1555-3892
09636897
Relation: https://doaj.org/toc/0963-6897; https://doaj.org/toc/1555-3892
DOI: 10.1177/0963689719857649
URL الوصول: https://doaj.org/article/73510641b3f14a698996d0de1a1c137c
رقم الأكسشن: edsdoj.73510641b3f14a698996d0de1a1c137c
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:09636897
15553892
DOI:10.1177/0963689719857649