دورية أكاديمية
أعرض في EDS

Liver Resection and Transplantation Following Yttrium-90 Radioembolization for Primary Malignant Liver Tumors: A 15-Year Single-Center Experience

التفاصيل البيبلوغرافية
العنوان: Liver Resection and Transplantation Following Yttrium-90 Radioembolization for Primary Malignant Liver Tumors: A 15-Year Single-Center Experience
المؤلفون: Daniel Aliseda, Pablo Martí-Cruchaga, Gabriel Zozaya, Macarena Rodríguez-Fraile, José I. Bilbao, Alberto Benito-Boillos, Antonio Martínez De La Cuesta, Luis Lopez-Olaondo, Francisco Hidalgo, Mariano Ponz-Sarvisé, Ana Chopitea, Javier Rodríguez, Mercedes Iñarrairaegui, José Ignacio Herrero, Fernando Pardo, Bruno Sangro, Fernando Rotellar
المصدر: Cancers, Vol 15, Iss 3, p 733 (2023)
بيانات النشر: MDPI AG, 2023.
سنة النشر: 2023
المجموعة: LCC:Neoplasms. Tumors. Oncology. Including cancer and carcinogens
مصطلحات موضوعية: radioembolization, liver transplantation, liver resection, hepatocellular carcinoma, intrahepatic cholangiocarcinoma, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
الوصف: Radioembolization (RE) may help local control and achieve tumor reduction while hypertrophies healthy liver and provides a test of time. For liver transplant (LT) candidates, it may attain downstaging for initially non-candidates and bridging during the waitlist. Methods: Patients diagnosed with HCC and ICC treated by RE with further liver resection (LR) or LT between 2005–2020 were included. All patients selected were discarded for the upfront surgical approach for not accomplishing oncological or surgical safety criteria after a multidisciplinary team assessment. Data for clinicopathological details, postoperative, and survival outcomes were retrospectively reviewed from a prospectively maintained database. Results: A total of 34 patients underwent surgery following RE (21 LR and 13 LT). Clavien–Dindo grade III-IV complications and mortality rates were 19.0% and 9.5% for LR and 7.7% and 0% for LT, respectively. After RE, for HCC and ICC patients in the LR group, 10-year OS rates were 57% and 60%, and 10-year DFS rates were 43.1% and 60%, respectively. For HCC patients in the LT group, 10-year OS and DFS rates from RE were 51.3% and 43.3%, respectively. Conclusion: Liver resection after RE is safe and feasible with optimal short-term outcomes. Patients diagnosed with unresectable or high biological risk HCC or ICC, treated with RE, and rescued by LR may achieve optimal global and DFS rates. On the other hand, bridging or downstaging strategies to LT with RE in HCC patients show adequate recurrence rates as well as long-term survival.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 15030733
2072-6694
Relation: https://www.mdpi.com/2072-6694/15/3/733; https://doaj.org/toc/2072-6694
DOI: 10.3390/cancers15030733
URL الوصول: https://doaj.org/article/73515d050a4d429c8431b9e56b84d558
رقم الأكسشن: edsdoj.73515d050a4d429c8431b9e56b84d558
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:15030733
20726694
DOI:10.3390/cancers15030733