دورية أكاديمية
BTK inhibitors approved in Canada for CLL: Strategies for adverse event management
| العنوان: | BTK inhibitors approved in Canada for CLL: Strategies for adverse event management |
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| المؤلفون: | Nicole Dunse, Irene Hibbert, Sarah Doucette, Anna Christofides |
| المصدر: | Canadian Oncology Nursing Journal, Vol 31, Iss 0, Pp 1-11 (2021) |
| بيانات النشر: | Pappin Communications, 2021. |
| سنة النشر: | 2021 |
| المجموعة: | LCC:Neoplasms. Tumors. Oncology. Including cancer and carcinogens |
| مصطلحات موضوعية: | Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282 |
| الوصف: | Bruton tyrosine kinase (BTK) inhibitors are an effective therapy for the treatment of chronic lymphocytic leukemia (CLL), particularly in patients who present with high-risk features. The first-in-class BTK inhibitor, ibrutinib, is generally tolerable. However, unique adverse events (AEs) of concern, including cardiovascular toxicity and bleeding have been observed, prompting the development of next-generation inhibitors, such as acalabrutinib, with an improved safety profile. Nevertheless, as BTK inhibitors are given as a continuous therapy, and therapy interruptions have been associated with decreased efficacy, appropriate management of AEs related to any agent within this class is critical for optimizing outcomes. This paper will serve as a learning resource for Canadian oncology nurses on the BTK inhibitors currently approved in Canada for the treatment of CLL. It includes a description of the unique safety profiles of the BTK inhibitors and suggests strategies for monitoring and managing related AEs. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English French |
| تدمد: | 1181-912X 2368-8076 |
| Relation: | https://canadianoncologynursingjournal.com/index.php/conj/article/view/1203; https://doaj.org/toc/1181-912X; https://doaj.org/toc/2368-8076 |
| URL الوصول: | https://doaj.org/article/7372ed08c69d47abaaa648a267052a8a |
| رقم الأكسشن: | edsdoj.7372ed08c69d47abaaa648a267052a8a |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 1181912X 23688076 |
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