دورية أكاديمية
أعرض في EDS

Wild type, dEX3 and 2B survivin isoforms localize to the tumor cell plasma membrane, are secreted in exosomes, and interact with extracellular tubulin

التفاصيل البيبلوغرافية
العنوان: Wild type, dEX3 and 2B survivin isoforms localize to the tumor cell plasma membrane, are secreted in exosomes, and interact with extracellular tubulin
المؤلفون: Sheila Figel, Meaghan Birkemeier, Sanam Sahjram Dharma, Tara Barone, Emma Steinmetz, Michael Ciesielski, Robert Fenstermaker
المصدر: Biochemistry and Biophysics Reports, Vol 28, Iss , Pp 101174- (2021)
بيانات النشر: Elsevier, 2021.
سنة النشر: 2021
المجموعة: LCC:Biology (General)
LCC:Biochemistry
مصطلحات موضوعية: Survivin, Survivin-2B, Survivin-dEX3, Exosome, Plasma membrane, Tubulin, Biology (General), QH301-705.5, Biochemistry, QD415-436
الوصف: The Inhibitor of Apoptosis Protein survivin (svn) is upregulated in nearly all types of cancer and represents a promising therapeutic target. Localization to specific subcellular compartments and interactions with various binding partners allow survivin to play diverse roles in apoptosis resistance and mitosis. Survivin has recently been found in two extracellular compartments: the outer plasma membrane and secreted exosomes. In addition to svn-wt, splice variants svn-dEX3 and svn-2B are also overexpressed in human tumors. Here we show that, similarly to svn-wt, svn-dEX3 and svn-2B can be displayed on the outer plasma membrane, and secreted in exosomes. Additionally, we have identified a novel interaction of all three forms of survivin with secreted tubulin.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 2405-5808
Relation: http://www.sciencedirect.com/science/article/pii/S2405580821002685; https://doaj.org/toc/2405-5808
DOI: 10.1016/j.bbrep.2021.101174
URL الوصول: https://doaj.org/article/7384950b302c4a2e83e8329711c4cf61
رقم الأكسشن: edsdoj.7384950b302c4a2e83e8329711c4cf61
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:24055808
DOI:10.1016/j.bbrep.2021.101174