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The steep road to nonviral nanomedicines: Frequent challenges and culprits in designing nanoparticles for gene therapy

التفاصيل البيبلوغرافية
العنوان: The steep road to nonviral nanomedicines: Frequent challenges and culprits in designing nanoparticles for gene therapy
المؤلفون: Yao Yao, Yeongun Ko, Grant Grasman, Jeffery E. Raymond, Joerg Lahann
المصدر: Beilstein Journal of Nanotechnology, Vol 14, Iss 1, Pp 351-361 (2023)
بيانات النشر: Beilstein-Institut, 2023.
سنة النشر: 2023
المجموعة: LCC:Technology
LCC:Chemical technology
LCC:Science
LCC:Physics
مصطلحات موضوعية: characterization, dosage, gene delivery, uptake, transfection, Technology, Chemical technology, TP1-1185, Science, Physics, QC1-999
الوصف: The potential of therapeutically loaded nanoparticles (NPs) has been successfully demonstrated during the last decade, with NP-mediated nonviral gene delivery gathering significant attention as highlighted by the broad clinical acceptance of mRNA-based COVID-19 vaccines. A significant barrier to progress in this emerging area is the wild variability of approaches reported in published literature regarding nanoparticle characterizations. Here, we provide a brief overview of the current status and outline important concerns regarding the need for standardized protocols to evaluate NP uptake, NP transfection efficacy, drug dose determination, and variability of nonviral gene delivery systems. Based on these concerns, we propose wide adherence to multimodal, multiparameter, and multistudy analysis of NP systems. Adoption of these proposed approaches will ensure improved transparency, provide a better basis for interlaboratory comparisons, and will simplify judging the significance of new findings in a broader context, all critical requirements for advancing the field of nonviral gene delivery.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 2190-4286
Relation: https://doaj.org/toc/2190-4286
DOI: 10.3762/bjnano.14.30
URL الوصول: https://doaj.org/article/7393c299a85f4e9186ee06377370ea39
رقم الأكسشن: edsdoj.7393c299a85f4e9186ee06377370ea39
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:21904286
DOI:10.3762/bjnano.14.30