دورية أكاديمية
Biological and psychological predictors of posttraumatic stress disorder onset and chronicity. A one-year prospective study
| العنوان: | Biological and psychological predictors of posttraumatic stress disorder onset and chronicity. A one-year prospective study |
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| المؤلفون: | C. Gandubert, J. Scali, M-L. Ancelin, I. Carrière, A-M. Dupuy, G. Bagnolini, K. Ritchie, M. Sebanne, L. Martrille, E. Baccino, A. Hermès, J. Attal, I. Chaudieu |
| المصدر: | Neurobiology of Stress, Vol 3, Iss C, Pp 61-67 (2016) |
| بيانات النشر: | Elsevier, 2016. |
| سنة النشر: | 2016 |
| المجموعة: | LCC:Neurosciences. Biological psychiatry. Neuropsychiatry LCC:Neurology. Diseases of the nervous system LCC:Neurophysiology and neuropsychology |
| مصطلحات موضوعية: | Cortisol, Norepinephrine, Peritraumatic reaction, PTSD, Waist-to-hip-ratio, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571, Neurology. Diseases of the nervous system, RC346-429, Neurophysiology and neuropsychology, QP351-495 |
| الوصف: | Background: Few studies have prospectively examined risk factors for posttraumatic stress disorder (PTSD) in the aftermath of a traumatic exposure. The aim of this study is to identify the concurrent influence of psychological and biological diatheses on PTSD onset and maintenance, taking into account socio-demographic factors and psychiatric antecedents. Methods: A total of 123 civilians (61.8% of women) recruited in emergency units, were assessed using validated instruments during the first week and then at 1, 4, and 12 months post-trauma. Baseline assessment included evaluation of the psychological diathesis (i.e. psychiatric history and peritraumatic distress and dissociation), and the biological diathesis [i.e. cortisol, norepinephrine, epinephrine, c-reactive protein, total cholesterol, HDL cholesterol, glycosylated haemoglobin, waist-to-hip ratio (WHR), body mass index, diastolic and systolic blood pressure (SBP), and heart rate]. Results: Multivariate logistic regression analyses demonstrated both psychological and biological diatheses to be independent risk factors for PTSD. Peritraumatic distress and dissociation predicted onset (1-month) and mid-term PTSD (4-months), respectively. PTSD risk was associated positively with SBP and negatively with WHR, throughout the follow-up. In addition, a higher level of 12 h-overnight urinary norepinephrine independently predicted mid-term PTSD (4-months). Conclusions: This prospective study shows that peritraumatic psychological and biological markers are independent predictors of PTSD onset with specificities according to the stage of PTSD development; the psychological diathesis, i.e. peritraumatic distress and dissociation, being a better predictor of short-term dysfunction whereas biological diathesis was also predictive of development and maintenance of PTSD. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2352-2895 |
| Relation: | http://www.sciencedirect.com/science/article/pii/S2352289515300163; https://doaj.org/toc/2352-2895 |
| DOI: | 10.1016/j.ynstr.2016.02.002 |
| URL الوصول: | https://doaj.org/article/73a2606048784252bdf316f2aad51f75 |
| رقم الأكسشن: | edsdoj.73a2606048784252bdf316f2aad51f75 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 23522895 |
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| DOI: | 10.1016/j.ynstr.2016.02.002 |