دورية أكاديمية
Serum adiponectin-levels are predictive of posttraumatic stress disorder in women
| العنوان: | Serum adiponectin-levels are predictive of posttraumatic stress disorder in women |
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| المؤلفون: | Eileen Vuong, Shibe Mhlongo, Esnat Chirwa, Carl Lombard, Nasheeta Peer, Sian Megan Hemmings, Naeemah Abrahams, Soraya Seedat |
| المصدر: | Neurobiology of Stress, Vol 20, Iss , Pp 100477- (2022) |
| بيانات النشر: | Elsevier, 2022. |
| سنة النشر: | 2022 |
| المجموعة: | LCC:Neurosciences. Biological psychiatry. Neuropsychiatry LCC:Neurology. Diseases of the nervous system LCC:Neurophysiology and neuropsychology |
| مصطلحات موضوعية: | Adiponectin, Biomarker, Post-traumatic stress disorder, Posttraumatic stress symptoms, Rape, Trauma, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571, Neurology. Diseases of the nervous system, RC346-429, Neurophysiology and neuropsychology, QP351-495 |
| الوصف: | Background: Accumulative evidence indicates a role for adiponectin, a polypeptide secreted by adipose tissue, in the pathophysiology of posttraumatic disorder (PTSD) via metabolic and inflammatory pathways. This study examined adiponectin as a potential predictive biomarker for PTSD among female rape survivors. Methods: We evaluated the relationship of baseline serum adiponectin levels to the development of probable PTSD at 3- and 6-months post rape-exposure and compared adiponectin levels between 542 rape-exposed (RE) and 593 rape-unexposed women (RUE). Probable PTSD were defined as a Davidson Trauma Scale score ≥40. Data were analysed using multivariate regression models and a generalized estimating equation (GEE) model. We adjusted for clinically relevant covariates associated with PTSD, as well as adiposity indices. Results: Participants who were in the mid-and high adiponectin tertile groups versus the lowest tertile group had a significantly reduced risk of probable PTSD at 6 months follow-up, independent of adiposity(aOR = 0.45[0.22–1.05], p = 0.035; aOR = 0.44[0.22–0.90], p = 0.024). However, there was no effect of group (RE vs. RUE). Limitations: Adiponectin assays were conducted on non-fasting blood samples and information on chronic medication, dietary factors and levels of physical activity were not collected. There was a high attrition rate among rape exposed participants. Conclusions: Our results show that higher serum adiponectin levels are associated with reduced risk of probable PTSD over a 6-month period. This finding supports the hypothesis that serum adiponectin is a potential risk biomarker for PTSD. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2352-2895 |
| Relation: | http://www.sciencedirect.com/science/article/pii/S2352289522000522; https://doaj.org/toc/2352-2895 |
| DOI: | 10.1016/j.ynstr.2022.100477 |
| URL الوصول: | https://doaj.org/article/73ec6412e8f9449eba5d1c5fce2a462d |
| رقم الأكسشن: | edsdoj.73ec6412e8f9449eba5d1c5fce2a462d |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 23522895 |
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| DOI: | 10.1016/j.ynstr.2022.100477 |