دورية أكاديمية
Family history of pre-eclampsia and cardiovascular disease as risk factors for pre-eclampsia: the GenPE case-control study
| العنوان: | Family history of pre-eclampsia and cardiovascular disease as risk factors for pre-eclampsia: the GenPE case-control study |
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| المؤلفون: | Norma C Serrano, Doris Cristina Quintero-Lesmes, Frank Dudbridge, Lydia J Leon, Aroon D Hingorani, David J Williams, Juan P Casas |
| المصدر: | Hypertension in Pregnancy, Vol 39, Iss 1, Pp 56-63 (2020) |
| بيانات النشر: | Taylor & Francis Group, 2020. |
| سنة النشر: | 2020 |
| المجموعة: | LCC:Gynecology and obstetrics |
| مصطلحات موضوعية: | pre-eclampsia, family history, cardiovascular disease, Gynecology and obstetrics, RG1-991 |
| الوصف: | Objective: To determine whether family history of pre-eclampsia and cardiovascular disease is consistently associated with the occurrence of pre-eclampsia sub-phenotypes and fetal growth restriction (FGR). Material and Methods: We conducted a case-control study in which cases of pre-eclampsia and healthy pregnant controls were recruited at the time of delivery from eight Colombian cities between 2000 and 2012. Odds of pre-eclampsia among women with a positive family history of pre-eclampsia or cardiovascular disease were compared to women without affected relatives (logistic regression modeling and multinomial logistic regression model [Ajusted]). Results: A total of 3510 pre-eclampsia cases and 4512 controls with data on family history of pre-eclampsia were included in analyses. A subsample of 3086 cases and 3888 controls also provided information on family history of cardiovascular disease. Women whose mothers had pre-eclampsia had 3.38 (95% CI 2.89, 3.96) higher odds than those who did not, and having an affected sister increased pre-eclampsia odds by 2.43 (95% CI 2.02, 2.93). The effect of having both mother and sister affected with pre-eclampsia was stronger than the two independent risk factors (OR 4.17 [95% CI 2.60, 6.69]). Women with parental history of cardiovascular disease also had an increased risk of pre-eclampsia (OR 1.58 [95% CI 1.24, 2.01]). Conclusions: Family history of pre-eclampsia increased the risk of PE. The impact of family history of cardiovascular disease on pre-eclampsia was more conservative, but serves to support the hypothesis that pre-eclampsia may reflect the premature exposure of underlying cardiovascular dysfunction, precipitated by the stress test of pregnancy. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1064-1955 1525-6065 10641955 |
| Relation: | https://doaj.org/toc/1064-1955; https://doaj.org/toc/1525-6065 |
| DOI: | 10.1080/10641955.2019.1704003 |
| URL الوصول: | https://doaj.org/article/7419dc01ce7d47e4bb4c6aac1626b73b |
| رقم الأكسشن: | edsdoj.7419dc01ce7d47e4bb4c6aac1626b73b |
| قاعدة البيانات: | Directory of Open Access Journals |
PDF full text from Publisher | تدمد: | 10641955 15256065 |
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| DOI: | 10.1080/10641955.2019.1704003 |