دورية أكاديمية

Potential Therapeutic Implication of Herbal Medicine in Mitochondria-Mediated Oxidative Stress-Related Liver Diseases

التفاصيل البيبلوغرافية
العنوان: Potential Therapeutic Implication of Herbal Medicine in Mitochondria-Mediated Oxidative Stress-Related Liver Diseases
المؤلفون: Moon Nyeo Park, Md. Ataur Rahman, Md. Hasanur Rahman, Jong Woo Kim, Min Choi, Jeong Woo Kim, Jinwon Choi, Myunghan Moon, Kazi Rejvee Ahmed, Bonglee Kim
المصدر: Antioxidants, Vol 11, Iss 10, p 2041 (2022)
بيانات النشر: MDPI AG, 2022.
سنة النشر: 2022
المجموعة: LCC:Therapeutics. Pharmacology
مصطلحات موضوعية: nonalcoholic fatty liver disease (NAFLD), herbal medicine, catechol-containing antioxidants, mitochondria, oxidative stress, liver diseases, Therapeutics. Pharmacology, RM1-950
الوصف: Mitochondria are double-membrane organelles that play a role in ATP synthesis, calcium homeostasis, oxidation-reduction status, apoptosis, and inflammation. Several human disorders have been linked to mitochondrial dysfunction. It has been found that traditional therapeutic herbs are effective on alcoholic liver disease (ALD) and nonalcoholic fatty liver disease (NAFLD) which are leading causes of liver cirrhosis and hepatocellular carcinoma. The generation of reactive oxygen species (ROS) in response to oxidative stress is caused by mitochondrial dysfunction and is considered critical for treatment. The role of oxidative stress, lipid toxicity, and inflammation in NAFLD are well known. NAFLD is a chronic liver disease that commonly progresses to cirrhosis and chronic liver disease, and people with obesity, insulin resistance, diabetes, hyperlipidemia, and hypertension are at a higher risk of developing NAFLD. NAFLD is associated with a number of pathological factors, including insulin resistance, lipid metabolic dysfunction, oxidative stress, inflammation, apoptosis, and fibrosis. As a result, the improvement in steatosis and inflammation is enough to entice researchers to look into liver disease treatment. However, antioxidant treatment has not been very effective for liver disease. Additionally, it has been suggested that the beneficial effects of herbal medicines on immunity and inflammation are governed by various mechanisms for lipid metabolism and inflammation control. This review provided a summary of research on herbal medicines for the therapeutic implementation of mitochondria-mediated ROS production in liver disease as well as clinical applications through herbal medicine. In addition, the pathophysiology of common liver disorders such as ALD and NAFLD would be investigated in the role that mitochondria play in the process to open new therapeutic avenues in the management of patients with liver disease.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 2076-3921
Relation: https://www.mdpi.com/2076-3921/11/10/2041; https://doaj.org/toc/2076-3921
DOI: 10.3390/antiox11102041
URL الوصول: https://doaj.org/article/741d1fbd562d4627a572a004369a243f
رقم الأكسشن: edsdoj.741d1fbd562d4627a572a004369a243f
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:20763921
DOI:10.3390/antiox11102041