دورية أكاديمية
Pharmacologicaly activities of Azanza garckeana (Goron Tula) grown in Nigeria
| العنوان: | Pharmacologicaly activities of Azanza garckeana (Goron Tula) grown in Nigeria |
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| المؤلفون: | Abubakar Awwal Yusuf, Bashir Lawal, Saidu Sani, Rahinat Garba, Bala Alkali Mohammed, David Bini Oshevire, Daniel Anuoluwa Adesina |
| المصدر: | Clinical Phytoscience, Vol 6, Iss 1, Pp 1-8 (2020) |
| بيانات النشر: | SpringerOpen, 2020. |
| سنة النشر: | 2020 |
| المجموعة: | LCC:Medicine LCC:Homeopathy |
| مصطلحات موضوعية: | Azanza garckeana, Phytochemicals, Pharmacological activities, Medicine, Homeopathy, RX1-681 |
| الوصف: | Abstract Background The present study evaluated the phytochemical profiles, anti-oxidants, antimicrobial, anti-inflammatory, analgesic, anti-arthritic and wound healing effect of methanol and ethyl-acetate extracts of Azanza garckeana. Results Methanol extract had higher phenol, flavonoids and alkaloids concentrations, ferric reducing antioxidant power (FRAP) and hydroxyl radical scavenging activities than ethyl-acetate extract. Ethyl-acetate and methanol extracts had IC50 of 119.40 μg/mL and 133.49 μg/mL respectively against 2,2-diphenyl-1-picrylhydrazyl radical (DPPH) radicals. The extracts were more active against Klebsiella pneumonia while the least activity was recoded against Bacillus subtilis with methanol been most potent than ethyl-acetate. The IC50 value of methanol extract in inhibition of protein denaturation were 310.44 μg/mL and 315.27 μg/mL while IC50 value of 354.74 μg/mL and 349.57 μg/mL were recorded for membrane stabilization effect in bovine serum albumin (BSA) and egg albumin (EGA) assays respectively. There was dose dependent in vivo anti-inflammatory and analgesic activities with highest percentage paw oedema inhibitions of 51.68% and analgesia of 46.36% at 600 mg/kg bw of the methanol extract. The extract caused dosed independent increase percentage wound closure with percentage wound contraction range between 65.24 ± 2.46 and 69.68 ± .2.54 compare to untreated wound (15.35 ± 0.35 to 50.35 ± 2.35%). Conclusion This study lends pharmacological support to folkloric usage of Azanza garckeana in the treatment and management of several human disease. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2199-1197 86595024 |
| Relation: | http://link.springer.com/article/10.1186/s40816-020-00173-0; https://doaj.org/toc/2199-1197 |
| DOI: | 10.1186/s40816-020-00173-0 |
| URL الوصول: | https://doaj.org/article/741ea76dbcf74df2adfd86595024937a |
| رقم الأكسشن: | edsdoj.741ea76dbcf74df2adfd86595024937a |
| قاعدة البيانات: | Directory of Open Access Journals |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 21991197 86595024 |
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| DOI: | 10.1186/s40816-020-00173-0 |