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أعرض في EDS

Sacituzumab Govitecan (IMMU-132) in treatment-resistant uterine serous carcinoma: A case report

التفاصيل البيبلوغرافية
العنوان: Sacituzumab Govitecan (IMMU-132) in treatment-resistant uterine serous carcinoma: A case report
المؤلفون: Chanhee Han, Stefania Bellone, Peter E. Schwartz, Serengulam V. Govindan, Robert M. Sharkey, David M. Goldenberg, Alessandro D. Santin
المصدر: Gynecologic Oncology Reports, Vol 25, Iss , Pp 37-40 (2018)
بيانات النشر: Elsevier, 2018.
سنة النشر: 2018
المجموعة: LCC:Gynecology and obstetrics
LCC:Neoplasms. Tumors. Oncology. Including cancer and carcinogens
مصطلحات موضوعية: Gynecology and obstetrics, RG1-991, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
الوصف: Background: Uterine serous carcinoma (USC) is a biologically aggressive variant of uterine cancer. Effective treatment options for recurrent, chemotherapy-resistant USC are extremely limited. Case: We describe a 74-year-old woman with recurrent and widespread treatment-resistant disease, who experienced a dramatic response to sacituzumab govitecan, a novel antibody-drug conjugate (ADC) targeting human trophoblast-cell-surface antigen (TROP-2), after failing multiple chemotherapy and immunotherapy. The impressive clinical response (66% reduction of target lesions by RECIST 1.1 with a duration response of over 10 months) was confirmed with serial CT scans in the absence of significant adverse events. Conclusion: Sacituzumab govitecan may present a new treatment option for recurrent USC patients harboring Trop-2+ tumors resistant to chemotherapy. Clinical trials with sacituzumab govitecan are warranted. Keywords: Sacituzumab govitecan, IMMU-132, Uterine serous carcinoma, Recurrent, Treatment-resistant
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 2352-5789
Relation: http://www.sciencedirect.com/science/article/pii/S2352578918300456; https://doaj.org/toc/2352-5789
DOI: 10.1016/j.gore.2018.05.009
URL الوصول: https://doaj.org/article/74797ae50e014372b68ce8d0349dfbd7
رقم الأكسشن: edsdoj.74797ae50e014372b68ce8d0349dfbd7
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:23525789
DOI:10.1016/j.gore.2018.05.009