Flávia Alvim Sant’Anna Addor,1 Juliana Cotta Vieira,2 Camila Sirieiro Abreu Melo2 1MEDCIN Research, Osasco, Brazil; 2Farmoquímica S.A., Rio de Janeiro, Brazil Purpose: Skin aging is a progressive and degenerative process caused by a decrease in the physiological functions of the skin tissue. In addition, environmental factors as well as concomitant diseases and lifestyle (nutrition, sedentary lifestyle, smoking, etc) negatively impact the aging process. An association between oral administration of collagen peptides combined with vitamin C and extracts of Hibiscus sabdariffa and Aristotelia chilensis (Delphynol®) (Eximia Firmalize Age complex®) on dermal thickness was studied and the improvement in aging signs was evaluated.Patients and methods: Female adult patients received an oral nutritional supplement containing collagen peptides, vitamin C, H. sabdariffa, and A. chilensis (Delphynol) in a sachet and were instructed to consume 1 sachet diluted in 200 mL of water once daily for 12 weeks. They were evaluated clinically, by high frequency ultrasound and cutometry.Results: There was a significant improvement of firmness and elasticity and an increase in dermal thickness by ultrasound after 3 months of use.Conclusion: The association of collagen peptides, vitamin C, H. sabdariffa and A. chilensis (Delphynol) could improve the signs of dermal skin aging. Keywords: aging, collagen, ultrasound, dermis, antioxidant, flavonoids, peptides
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