دورية أكاديمية
Emerging roles of miR-145 in gastrointestinal cancers: A new paradigm
| العنوان: | Emerging roles of miR-145 in gastrointestinal cancers: A new paradigm |
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| المؤلفون: | Mohammad Roshani, Danial Molavizadeh, Sara Sadeghi, Ameneh Jafari, Fatemeh Dashti, Seyed Mohammad Ali Mirazimi, Sahar Ahmadi Asouri, Ali Rajabi, Michael R. Hamblin, Ali Arash Anoushirvani, Hamed Mirzaei |
| المصدر: | Biomedicine & Pharmacotherapy, Vol 166, Iss , Pp 115264- (2023) |
| بيانات النشر: | Elsevier, 2023. |
| سنة النشر: | 2023 |
| المجموعة: | LCC:Therapeutics. Pharmacology |
| مصطلحات موضوعية: | Gastrointestinal cancers, MicroRNA, MiR-145, Tumor suppressor, Therapeutics. Pharmacology, RM1-950 |
| الوصف: | Gastrointestinal (GI) carcinomas are a group of cancers affecting the GI tract and digestive organs, such as the gastric, liver, bile ducts, pancreas, small intestine, esophagus, colon, and rectum. MicroRNAs (miRNAs) are small functional non-coding RNAs (ncRNAs) which are involved in regulating the expression of multiple target genes; mainly at the post-transcriptional level, via complementary binding to their 3′‐untranslated region (3′‐UTR). Increasing evidence has shown that miRNAs have critical roles in modulating of various physiological and pathological cellular processes and regulating the occurrence and development of human malignancies. Among them, miR-145 is recognized for its anti-oncogenic properties in various cancers, including GI cancers. MiR-145 has been implicated in diverse biological processes of cancers through the regulation of target genes or signaling, including, proliferation, differentiation, tumorigenesis, angiogenesis, apoptosis, metastasis, and therapy resistance. In this review, we have summarized the role of miR-145 in selected GI cancers and also its downstream molecules and cellular processes targets, which could lead to a better understanding of the miR-145 in these cancers. In conclusion, we reveal the potential diagnostic, prognostic, and therapeutic value of miR-145 in GI cancer, and hope to provide new ideas for its application as a biomarker as well as a therapeutic target for the treatment of these cancer. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 0753-3322 90354702 |
| Relation: | http://www.sciencedirect.com/science/article/pii/S0753332223010557; https://doaj.org/toc/0753-3322 |
| DOI: | 10.1016/j.biopha.2023.115264 |
| URL الوصول: | https://doaj.org/article/e74d4b59bd444a069d90354702c0005d |
| رقم الأكسشن: | edsdoj.74d4b59bd444a069d90354702c0005d |
| قاعدة البيانات: | Directory of Open Access Journals |
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Full Text Finder | تدمد: | 07533322 90354702 |
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| DOI: | 10.1016/j.biopha.2023.115264 |