دورية أكاديمية

Current Knowledge about the Effect of Nutritional Status, Supplemented Nutrition Diet, and Gut Microbiota on Hepatic Ischemia-Reperfusion and Regeneration in Liver Surgery

التفاصيل البيبلوغرافية
العنوان: Current Knowledge about the Effect of Nutritional Status, Supplemented Nutrition Diet, and Gut Microbiota on Hepatic Ischemia-Reperfusion and Regeneration in Liver Surgery
المؤلفون: María Eugenia Cornide-Petronio, Ana Isabel Álvarez-Mercado, Mónica B. Jiménez-Castro, Carmen Peralta
المصدر: Nutrients, Vol 12, Iss 2, p 284 (2020)
بيانات النشر: MDPI AG, 2020.
سنة النشر: 2020
المجموعة: LCC:Nutrition. Foods and food supply
مصطلحات موضوعية: ischemia-reperfusion injury, nutritional status, supplemented nutrition, gut microbiota, partial hepatectomy, liver transplantation, Nutrition. Foods and food supply, TX341-641
الوصف: Ischemia-reperfusion (I/R) injury is an unresolved problem in liver resection and transplantation. The preexisting nutritional status related to the gut microbial profile might contribute to primary non-function after surgery. Clinical studies evaluating artificial nutrition in liver resection are limited. The optimal nutritional regimen to support regeneration has not yet been exactly defined. However, overnutrition and specific diet factors are crucial for the nonalcoholic or nonalcoholic steatohepatitis liver diseases. Gut-derived microbial products and the activation of innate immunity system and inflammatory response, leading to exacerbation of I/R injury or impaired regeneration after resection. This review summarizes the role of starvation, supplemented nutrition diet, nutritional status, and alterations in microbiota on hepatic I/R and regeneration. We discuss the most updated effects of nutritional interventions, their ability to alter microbiota, some of the controversies, and the suitability of these interventions as potential therapeutic strategies in hepatic resection and transplantation, overall highlighting the relevance of considering the extended criteria liver grafts in the translational liver surgery.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 2072-6643
Relation: https://www.mdpi.com/2072-6643/12/2/284; https://doaj.org/toc/2072-6643
DOI: 10.3390/nu12020284
URL الوصول: https://doaj.org/article/7529bd66a6a64f95867a8fb1e6ed2517
رقم الأكسشن: edsdoj.7529bd66a6a64f95867a8fb1e6ed2517
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:20726643
DOI:10.3390/nu12020284