دورية أكاديمية
Emergence and Spread of Extensively and Totally Drug-Resistant Tuberculosis, South Africa
| العنوان: | Emergence and Spread of Extensively and Totally Drug-Resistant Tuberculosis, South Africa |
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| المؤلفون: | Marisa Klopper, Robin Mark Warren, Cindy Hayes, Nicolaas Claudius Gey van Pittius, Elizabeth Maria Streicher, Borna Müller, Frederick Adriaan Sirgel, Mamisa Chabula-Nxiweni, Ebrahim Hoosain, Gerrit Coetzee, Paul David van Helden, Thomas Calldo Victor, André Phillip Trollip |
| المصدر: | Emerging Infectious Diseases, Vol 19, Iss 3, Pp 449-455 (2013) |
| بيانات النشر: | Centers for Disease Control and Prevention, 2013. |
| سنة النشر: | 2013 |
| المجموعة: | LCC:Medicine LCC:Infectious and parasitic diseases |
| مصطلحات موضوعية: | Tuberculosis, multidrug-resistant tuberculosis, MDR-TB, extensively drug-resistant tuberculosis, XDR-TB, totally drug-resistant tuberculosis, Medicine, Infectious and parasitic diseases, RC109-216 |
| الوصف: | Factors driving the increase in drug-resistant tuberculosis (TB) in the Eastern Cape Province, South Africa, are not understood. A convenience sample of 309 drug-susceptible and 342 multidrug-resistant (MDR) TB isolates, collected July 2008–July 2009, were characterized by spoligotyping, DNA fingerprinting, insertion site mapping, and targeted DNA sequencing. Analysis of molecular-based data showed diverse genetic backgrounds among drug-sensitive and MDR TB sensu stricto isolates in contrast to restricted genetic backgrounds among pre–extensively drug-resistant (pre-XDR) TB and XDR TB isolates. Second-line drug resistance was significantly associated with the atypical Beijing genotype. DNA fingerprinting and sequencing demonstrated that the pre-XDR and XDR atypical Beijing isolates evolved from a common progenitor; 85% and 92%, respectively, were clustered, indicating transmission. Ninety-three percent of atypical XDR Beijing isolates had mutations that confer resistance to 10 anti-TB drugs, and some isolates also were resistant to para-aminosalicylic acid. These findings suggest the emergence of totally drug-resistant TB. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1080-6040 1080-6059 |
| Relation: | https://wwwnc.cdc.gov/eid/article/19/3/12-0246_article; https://doaj.org/toc/1080-6040; https://doaj.org/toc/1080-6059 |
| DOI: | 10.3201/eid1903.120246 |
| URL الوصول: | https://doaj.org/article/752f256ee912498094a22ee579b6b62a |
| رقم الأكسشن: | edsdoj.752f256ee912498094a22ee579b6b62a |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 10806040 10806059 |
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| DOI: | 10.3201/eid1903.120246 |