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Insulin Resistance Estimated by HOMA IR for Diagnosis of Gestational Diabetes in Squatter Settlement of Karachi

التفاصيل البيبلوغرافية
العنوان: Insulin Resistance Estimated by HOMA IR for Diagnosis of Gestational Diabetes in Squatter Settlement of Karachi
المؤلفون: Hira Attique, Syed Tousif Ahmed, Rehana Rehman, Shahina Ishtiaque, Saeeda Baig
المصدر: Pakistan Journal of Medicine and Dentistry, Vol 9, Iss 1 (2020)
بيانات النشر: ziauddin University, 2020.
سنة النشر: 2020
المجموعة: LCC:Biochemistry
LCC:Dentistry
LCC:Therapeutics. Pharmacology
LCC:Medicine (General)
مصطلحات موضوعية: Biochemistry, QD415-436, Dentistry, RK1-715, Therapeutics. Pharmacology, RM1-950, Medicine (General), R5-920
الوصف: Background: Gestational diabetes mellitus (GDM), one of the most common metabolic disorders of pregnancy, is estimated to raise 16-27% worldwide every 10 years. Researchers, using Homeostasis model assessment test (HOMA IR), a tool for assessing insulin resistance, have found a number of causes. This study was designed to investigate the correlation between insulin resistance and GDM in the second trimester. Methods: This study recruited 84 pregnant women (24 to 28 weeks of gestation) from OPD of Gynaecology/Obstetrics and Family Medicine Department, Dr. Ziauddin Hospital Karachi Pakistan from May 2018 to January 2019. A thorough anthropometric measurements and antenatal history was recorded through structured questionnaire after informed consent. After 10 hours fast, venous blood (5ml) was drawn for fasting blood glucose (FBS), insulin levels and Glucose challenge test (GCT) for screening gestational diabetes. Results: Out of 84 subjects, 37 had higher GCT values while 47 had normal level. FBS was found significantly associated (p < 0.05). With GCT among GDM subjects 16(19%) had normal Body Mass Index (BMI) and 18(21.4%) had normal body fat percentage however, 2(2.4%) had high insulin levels and 13(15.5%) high FBS levels. The value HOMA IR, ≤1.29 was found in 38(45.2) healthy mothers and 25(29.8) GDM. Patients’ GCT had positive association with parity, FBS, insulin, HOMA IR and BMI. Conclusion: Linear strong positive correlation was found between insulin resistance and GCT in the second trimester. Patients with significantly higher GCT values and index value of HOMA IR greater than >1.29 are at risk for developing GDM.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 2313-7371
2308-2593
Relation: https://ojs.zu.edu.pk/pjmd/article/view/385; https://doaj.org/toc/2313-7371; https://doaj.org/toc/2308-2593
DOI: 10.36283/PJMD9-1/004
URL الوصول: https://doaj.org/article/7558de56e15a46899c2c95f29b30c28f
رقم الأكسشن: edsdoj.7558de56e15a46899c2c95f29b30c28f
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:23137371
23082593
DOI:10.36283/PJMD9-1/004