دورية أكاديمية
Cytokines and lymphocyte subsets are associated with disease severity of severe fever with thrombocytopenia syndrome
العنوان: | Cytokines and lymphocyte subsets are associated with disease severity of severe fever with thrombocytopenia syndrome |
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المؤلفون: | Li Song, Wenlu Zou, Gang Wang, Ling Qiu, Lintao Sai |
المصدر: | Virology Journal, Vol 21, Iss 1, Pp 1-6 (2024) |
بيانات النشر: | BMC, 2024. |
سنة النشر: | 2024 |
المجموعة: | LCC:Infectious and parasitic diseases |
مصطلحات موضوعية: | Severe fever with thrombocytopenia syndrome, Severity, Cytokines, Lymphocyte subsets, Predictors, Infectious and parasitic diseases, RC109-216 |
الوصف: | Abstract Background Severe fever with thrombocytopenia syndrome (SFTS) is an emerging infectious disease caused by severe fever with thrombocytopenia syndrome virus (SFTSV). Previous studies have indicated that SFTS patients have a high mortality rate, which may be related to cytokine storm and immune dysfunction. In our study, we analyzed differences in cytokines and lymphocyte subsets between severe and non-severe SFTS patients, with the aim of identifying predictors of severity. Methods We retrospectively analyzed demographic characteristics, clinical data, cytokine profiles, and lymphocyte subsets from 96 laboratory confirmed SFTS patients between April 2021 and August 2023. Results A total of 96 SFTS patients were enrolled, with a mean age of 65.05 (± 7.92) years old. According to our grouping criteria, 35 (36.5%) of these patients were classified as severe group, while 61 (63.5%) were classified as non-severe group. Univariate analysis revealed that age, interleukin-6 (IL-6), interleukin-8 (IL-8), interleukin-10 (IL-10), interferon-α (IFN-α), CD4 + T cell, and CD8 + T cell counts were risk predictors for the severity of SFTS. Further multivariable logistic regression analysis confirmed age, IL-6 levels, and CD4 + T cell counts as independent predictors of SFTS severity. Conclusions Severe SFTS patients may experience cytokine storms and immune dysfunction. Aging, elevated levels of IL-6, and decreased CD4 + T cell count may serve as independent predictors for the severity of SFTS. |
نوع الوثيقة: | article |
وصف الملف: | electronic resource |
اللغة: | English |
تدمد: | 1743-422X 75736292 |
Relation: | https://doaj.org/toc/1743-422X |
DOI: | 10.1186/s12985-024-02403-0 |
URL الوصول: | https://doaj.org/article/add75736292d4c53bd575c19e916bb00 |
رقم الأكسشن: | edsdoj.75736292d4c53bd575c19e916bb00 |
قاعدة البيانات: | Directory of Open Access Journals |
تدمد: | 1743422X 75736292 |
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DOI: | 10.1186/s12985-024-02403-0 |