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The role of protease inhibitors on the remineralization of demineralized dentin using the PILP method.

التفاصيل البيبلوغرافية
العنوان: The role of protease inhibitors on the remineralization of demineralized dentin using the PILP method.
المؤلفون: Hamid Nurrohman, Karina M M Carneiro, John Hellgeth, Kuniko Saeki, Sally J Marshall, Grayson W Marshall, Stefan Habelitz
المصدر: PLoS ONE, Vol 12, Iss 11, p e0188277 (2017)
بيانات النشر: Public Library of Science (PLoS), 2017.
سنة النشر: 2017
المجموعة: LCC:Medicine
LCC:Science
مصطلحات موضوعية: Medicine, Science
الوصف: Mineralized and sound dentin matrices contain inactive preforms of proteolytic enzymes that may be activated during the demineralization cycle. In this study, we tested the hypothesis that protease inhibitors (PI) preserve demineralized collagen fibrils and other constituents of the dentin matrix and thereby affect the potential for remineralization. Artificial carious lesions with lesion depths of 140 μm were created with acetate buffer (pH = 5.0, 66 hours), and remineralized using a polymer-induced-liquid-precursor (PILP) process (pH = 7.4, 14 days) containing poly(aspartic acid) (pAsp) as the process-directing agent. De- and remineralizing procedures were performed in the presence or absence of PI. Ultrastructure and mechanical recovery of demineralized dentin following PILP remineralization were examined and measured in water with atomic force microscopy (AFM) and nanoindentation. Nanomechanical properties of hydrated artificial lesions had a low elastic modulus (ER
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 1932-6203
Relation: http://europepmc.org/articles/PMC5705123?pdf=render; https://doaj.org/toc/1932-6203
DOI: 10.1371/journal.pone.0188277
URL الوصول: https://doaj.org/article/75c6080a8faa45b6b54f48867efe6efe
رقم الأكسشن: edsdoj.75c6080a8faa45b6b54f48867efe6efe
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:19326203
DOI:10.1371/journal.pone.0188277