Background: Emergency medical personnel are among the people who play a major role in reducing the mortality and disability of the injured. This study determines the relationship between mental health and job satisfaction with professional ethics in emergency medical personnel. Materials and Methods: The present cross-sectional study included 126 emergency medical personnel in Hamadan City, Iran. The data were collected using a 3-part demographic information questionnaire, the 28-item general health questionnaire, the Barry Field and Ruth job satisfaction questionnaire and the Cadozier professional ethics questionnaire. The data were analyzed using Stata software, version 14. Meanwhile, the significance level was considered P