دورية أكاديمية
Exploring the role of the outer subventricular zone during cortical folding through a physics-based model
| العنوان: | Exploring the role of the outer subventricular zone during cortical folding through a physics-based model |
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| المؤلفون: | Mohammad Saeed Zarzor, Ingmar Blumcke, Silvia Budday |
| المصدر: | eLife, Vol 12 (2023) |
| بيانات النشر: | eLife Sciences Publications Ltd, 2023. |
| سنة النشر: | 2023 |
| المجموعة: | LCC:Medicine LCC:Science LCC:Biology (General) |
| مصطلحات موضوعية: | outer subventricular zone, multifield modeling, human brain development, outer radial glial cells, finite element simulations, Medicine, Science, Biology (General), QH301-705.5 |
| الوصف: | The human brain has a highly complex structure both on the microscopic and on the macroscopic scales. Increasing evidence has suggested the role of mechanical forces for cortical folding – a classical hallmark of the human brain. However, the link between cellular processes at the microscale and mechanical forces at the macroscale remains insufficiently understood. Recent findings suggest that an additional proliferating zone, the outer subventricular zone (OSVZ), is decisive for the particular size and complexity of the human cortex. To better understand how the OSVZ affects cortical folding, we establish a multifield computational model that couples cell proliferation in different zones and migration at the cell scale with growth and cortical folding at the organ scale by combining an advection-diffusion model with the theory of finite growth. We validate our model based on data from histologically stained sections of the human fetal brain and predict 3D pattern formation. Finally, we address open questions regarding the role of the OSVZ for the formation of cortical folds. The presented framework not only improves our understanding of human brain development, but could eventually help diagnose and treat neuronal disorders arising from disruptions in cellular development and associated malformations of cortical development. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2050-084X |
| Relation: | https://elifesciences.org/articles/82925; https://doaj.org/toc/2050-084X |
| DOI: | 10.7554/eLife.82925 |
| URL الوصول: | https://doaj.org/article/75ee0f421fc0485986ab712a3ffec12c |
| رقم الأكسشن: | edsdoj.75ee0f421fc0485986ab712a3ffec12c |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 2050084X |
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| DOI: | 10.7554/eLife.82925 |