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أعرض في EDS

Pathogenesis, disease course, and prognosis of adult-onset Still's disease: an update and review

التفاصيل البيبلوغرافية
العنوان: Pathogenesis, disease course, and prognosis of adult-onset Still's disease: an update and review
المؤلفون: Meng-Yan Wang, Jin-Chao Jia, Cheng-De Yang, Qiong-Yi Hu, Li-Shao Guo
المصدر: Chinese Medical Journal, Vol 132, Iss 23, Pp 2856-2864 (2019)
بيانات النشر: Wolters Kluwer, 2019.
سنة النشر: 2019
المجموعة: LCC:Medicine
مصطلحات موضوعية: Medicine
الوصف: Abstract. Objective:. Adult-onset Still's disease (AOSD) is a rare but clinically well-known polygenic systemic autoinflammatory disease. In this review, we aim to present frontiers in the pathogenesis, clinical features, diagnosis, biomarkers, disease course, prognosis, and treatment in AOSD. Data sources:. We retrieved information from the PubMed database up to July 2019, using various search terms and relevant words, including AOSD and Still's disease. Study selection:. We included data from peer-reviewed journals. Both basic and clinical studies were selected. Results:. Pathogenesis of AOSD involves genetic background, infectious triggers, and immunopathogenesis, mainly the activation of macrophages and neutrophils followed by a cytokine storm. Diagnosis and prognosis evaluation of AOSD is still challenging; therefore, there is an urgent need to identify better biomarkers. Biologic agents, including interleukin (IL)-1β, IL-6, and tumor necrosis factor-α antagonists in the treatment of AOSD, have good prospect. Conclusion:. This review highlights the advances in pathogenesis, potential biomarkers, disease course, and treatment in AOSD.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 0366-6999
2542-5641
00000000
Relation: http://journals.lww.com/10.1097/CM9.0000000000000538; https://doaj.org/toc/0366-6999; https://doaj.org/toc/2542-5641
DOI: 10.1097/CM9.0000000000000538
URL الوصول: https://doaj.org/article/75ff9742aded4488be01310baad4c3a4
رقم الأكسشن: edsdoj.75ff9742aded4488be01310baad4c3a4
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:03666999
25425641
00000000
DOI:10.1097/CM9.0000000000000538