دورية أكاديمية
Pathogenesis, disease course, and prognosis of adult-onset Still's disease: an update and review
العنوان: | Pathogenesis, disease course, and prognosis of adult-onset Still's disease: an update and review |
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المؤلفون: | Meng-Yan Wang, Jin-Chao Jia, Cheng-De Yang, Qiong-Yi Hu, Li-Shao Guo |
المصدر: | Chinese Medical Journal, Vol 132, Iss 23, Pp 2856-2864 (2019) |
بيانات النشر: | Wolters Kluwer, 2019. |
سنة النشر: | 2019 |
المجموعة: | LCC:Medicine |
مصطلحات موضوعية: | Medicine |
الوصف: | Abstract. Objective:. Adult-onset Still's disease (AOSD) is a rare but clinically well-known polygenic systemic autoinflammatory disease. In this review, we aim to present frontiers in the pathogenesis, clinical features, diagnosis, biomarkers, disease course, prognosis, and treatment in AOSD. Data sources:. We retrieved information from the PubMed database up to July 2019, using various search terms and relevant words, including AOSD and Still's disease. Study selection:. We included data from peer-reviewed journals. Both basic and clinical studies were selected. Results:. Pathogenesis of AOSD involves genetic background, infectious triggers, and immunopathogenesis, mainly the activation of macrophages and neutrophils followed by a cytokine storm. Diagnosis and prognosis evaluation of AOSD is still challenging; therefore, there is an urgent need to identify better biomarkers. Biologic agents, including interleukin (IL)-1β, IL-6, and tumor necrosis factor-α antagonists in the treatment of AOSD, have good prospect. Conclusion:. This review highlights the advances in pathogenesis, potential biomarkers, disease course, and treatment in AOSD. |
نوع الوثيقة: | article |
وصف الملف: | electronic resource |
اللغة: | English |
تدمد: | 0366-6999 2542-5641 00000000 |
Relation: | http://journals.lww.com/10.1097/CM9.0000000000000538; https://doaj.org/toc/0366-6999; https://doaj.org/toc/2542-5641 |
DOI: | 10.1097/CM9.0000000000000538 |
URL الوصول: | https://doaj.org/article/75ff9742aded4488be01310baad4c3a4 |
رقم الأكسشن: | edsdoj.75ff9742aded4488be01310baad4c3a4 |
قاعدة البيانات: | Directory of Open Access Journals |
تدمد: | 03666999 25425641 00000000 |
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DOI: | 10.1097/CM9.0000000000000538 |