دورية أكاديمية
Increased longevity due to sexual activity in mole-rats is associated with transcriptional changes in the HPA stress axis
| العنوان: | Increased longevity due to sexual activity in mole-rats is associated with transcriptional changes in the HPA stress axis |
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| المؤلفون: | Arne Sahm, Matthias Platzer, Philipp Koch, Yoshiyuki Henning, Martin Bens, Marco Groth, Hynek Burda, Sabine Begall, Saskia Ting, Moritz Goetz, Paul Van Daele, Magdalena Staniszewska, Jasmin Mona Klose, Pedro Fragoso Costa, Steve Hoffmann, Karol Szafranski, Philip Dammann |
| المصدر: | eLife, Vol 10 (2021) |
| بيانات النشر: | eLife Sciences Publications Ltd, 2021. |
| سنة النشر: | 2021 |
| المجموعة: | LCC:Medicine LCC:Science LCC:Biology (General) |
| مصطلحات موضوعية: | Fukomys, lifespan, hypothalamic-pituitary-adrenal axis, ACTHR, differential gene expression, DHEA, Medicine, Science, Biology (General), QH301-705.5 |
| الوصف: | Sexual activity and/or reproduction are associated with a doubling of life expectancy in the long-lived rodent genus Fukomys. To investigate the molecular mechanisms underlying this phenomenon, we analyzed 636 RNA-seq samples across 15 tissues. This analysis suggests that changes in the regulation of the hypothalamic–pituitary–adrenal stress axis play a key role regarding the extended life expectancy of reproductive vs. non-reproductive mole-rats. This is substantiated by a corpus of independent evidence. In accordance with previous studies, the up-regulation of the proteasome and so-called ‘anti-aging molecules’, for example, dehydroepiandrosterone, is linked with enhanced lifespan. On the other hand, several of our results are not consistent with knowledge about aging of short-lived model organisms. For example, we found the up-regulation of the insulin-like growth factor 1/growth hormone axis and several other anabolic processes to be compatible with a considerable lifespan prolongation. These contradictions question the extent to which findings from short-lived species can be transferred to longer-lived ones. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2050-084X |
| Relation: | https://elifesciences.org/articles/57843; https://doaj.org/toc/2050-084X |
| DOI: | 10.7554/eLife.57843 |
| URL الوصول: | https://doaj.org/article/7604cc028b8242158c4940e90b47e895 |
| رقم الأكسشن: | edsdoj.7604cc028b8242158c4940e90b47e895 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 2050084X |
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| DOI: | 10.7554/eLife.57843 |