دورية أكاديمية
Column chromatography USED in purification of genotoxic impurity sample of imatinib mesylate substance
| العنوان: | Column chromatography USED in purification of genotoxic impurity sample of imatinib mesylate substance |
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| المؤلفون: | V. I. Krylov, S. V. Moiseev, O. V. Knyazkina, V. A. Yashkir, V. A. Merkulov |
| المصدر: | Ведомости Научного центра экспертизы средств медицинского применения, Vol 0, Iss 3, Pp 42-45 (2018) |
| بيانات النشر: | NEICON ISP LLC, 2018. |
| سنة النشر: | 2018 |
| المجموعة: | LCC:Medicine (General) |
| مصطلحات موضوعية: | n-(5-амино-2-метилфенил)-4-(3-пиридил)-2-пиримидинамин, иматиниба мезилат, генотоксичная примесь, колоночная хроматография, нейтральный оксид алюминия, вэжх, спектроскопия ямр, n-(5-amino-2-methylphenyl)-4-(3-pyridyl)-2-pyrimidinamine, imatinib mesylate, genotoxic impurity, column chromatography, neutral alumina, hplc, nmr spectroscopy, Medicine (General), R5-920 |
| الوصف: | The article describes a simple method for purifying N-(5-amino-2-methylphenyl)-4-(3-pyridyl)-2-pyrimidineamine for further use as a standard for quantitative determination of genotoxic impurities substance imatinib mesylate. Experimentally proved choice of sorbent used for purification of N-(5-amino-2-methylphenyl)-4-(3-pyridyl)-2-pyrimidineamine. The advantage of column chromatography on neutral alumina prior to crystallization methods presented in the literature. Comparative chromatographic and spectral characteristics of N-(5-amino-2-methylphenyl)-4-(3-pyridyl)-2-pyrimidineamine before and after purification. NMR spectroscopy evaluated quantitative content of the target substance in the purified sample. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | Russian |
| تدمد: | 1991-2919 2619-1172 |
| Relation: | https://www.vedomostincesmp.ru/jour/article/view/91; https://doaj.org/toc/1991-2919; https://doaj.org/toc/2619-1172 |
| URL الوصول: | https://doaj.org/article/7609fc020fa2478c8e81a781223aebc2 |
| رقم الأكسشن: | edsdoj.7609fc020fa2478c8e81a781223aebc2 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 19912919 26191172 |
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