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Induction of ferroptosis and apoptosis in endometrial cancer cells by dihydroisotanshinone I

التفاصيل البيبلوغرافية
العنوان: Induction of ferroptosis and apoptosis in endometrial cancer cells by dihydroisotanshinone I
المؤلفون: Ching-Yuan Wu, Yao-Hsu Yang, Yu-Shih Lin, Li-Hsin Shu, Hung-Te Liu, Yu-Huei Wu, Yu-Heng Wu
المصدر: Heliyon, Vol 9, Iss 11, Pp e21652- (2023)
بيانات النشر: Elsevier, 2023.
سنة النشر: 2023
المجموعة: LCC:Science (General)
LCC:Social sciences (General)
مصطلحات موضوعية: Dihydroisotanshinone I, Endometrial cancer, GPX4, ferroptosis, apoptosis, Science (General), Q1-390, Social sciences (General), H1-99
الوصف: Danshen, also known as Salvia miltiorrhiza, is a medicinal herb used in traditional Chinese medicine. Its potential impact on endometrial cancer has not been thoroughly investigated. This study aimed to examine the effect of dihydroisotanshinone I (DT), a compound found in Danshen, on the viability of ARK1 and ARK2 endometrial cancer cells and its mechanisms. The results showed that 10 μM DT inhibited cell viability of ARK1 and ARK2 cells by inducing apoptosis and ferroptosis, which was achieved by blocking the expression of GPX4. In vivo experiments using a xenograft nude mouse model indicated that DT treatment significantly reduced tumor volume without causing any adverse effects. These findings suggest that DT may be a potential therapeutic agent for inhibiting endometrial cancer cell viability, but further research is needed to confirm these results.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 2405-8440
Relation: http://www.sciencedirect.com/science/article/pii/S2405844023088606; https://doaj.org/toc/2405-8440
DOI: 10.1016/j.heliyon.2023.e21652
URL الوصول: https://doaj.org/article/ccc7625e55e8494aa451f06a33d54be6
رقم الأكسشن: edsdoj.7625e55e8494aa451f06a33d54be6
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:24058440
DOI:10.1016/j.heliyon.2023.e21652