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أعرض في EDS

Rivaroxaban, a Direct Factor Xa Inhibitor, Ameliorates Hypertensive Renal Damage Through Inhibition of the Inflammatory Response Mediated by Protease‐Activated Receptor Pathway

التفاصيل البيبلوغرافية
العنوان: Rivaroxaban, a Direct Factor Xa Inhibitor, Ameliorates Hypertensive Renal Damage Through Inhibition of the Inflammatory Response Mediated by Protease‐Activated Receptor Pathway
المؤلفون: Hiroaki Ichikawa, Michiko Shimada, Masato Narita, Ikuyo Narita, Yoshihiro Kimura, Makoto Tanaka, Tomohiro Osanai, Ken Okumura, Hirofumi Tomita
المصدر: Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 8, Iss 8 (2019)
بيانات النشر: Wiley, 2019.
سنة النشر: 2019
المجموعة: LCC:Diseases of the circulatory (Cardiovascular) system
مصطلحات موضوعية: albuminuria, podocytes, protease‐activated receptor‐2, renin‐angiotensin system, rivaroxaban, Diseases of the circulatory (Cardiovascular) system, RC666-701
الوصف: Background An enhanced renin‐angiotensin system causes hypertensive renal damage. Factor Xa not only functions in the coagulation cascade but also activates intracellular signaling through protease‐activated receptors (PAR). We investigated the effects of rivaroxaban, a factor Xa inhibitor, on hypertensive renal damage in hypertensive mice overexpressing renin (Ren‐TG). Methods and Results The 12‐ to 16‐week‐old Ren‐TG and wild‐type mice were orally administered with or without 6 or 12 mg/kg of rivaroxaban for 1 or 4 months. Plasma factor Xa was significantly increased in the Ren‐TG compared with the wild‐type mice and was reduced by 12 mg/kg of rivaroxaban (P
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 2047-9980
Relation: https://doaj.org/toc/2047-9980
DOI: 10.1161/JAHA.119.012195
URL الوصول: https://doaj.org/article/765653b6c33b43ebab7c4410ab1c1b97
رقم الأكسشن: edsdoj.765653b6c33b43ebab7c4410ab1c1b97
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:20479980
DOI:10.1161/JAHA.119.012195