دورية أكاديمية
Maternal exposure to deltamethrin during pregnancy and lactation impairs neurodevelopment of male offspring
| العنوان: | Maternal exposure to deltamethrin during pregnancy and lactation impairs neurodevelopment of male offspring |
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| المؤلفون: | Fei Hao, Ye Bu, Shasha Huang, Wanqi Li, Huiwen Feng, Yuan Wang |
| المصدر: | Ecotoxicology and Environmental Safety, Vol 274, Iss , Pp 116196- (2024) |
| بيانات النشر: | Elsevier, 2024. |
| سنة النشر: | 2024 |
| المجموعة: | LCC:Environmental pollution LCC:Environmental sciences |
| مصطلحات موضوعية: | deltamethrin, hippocampus, cerebellum, neurodevelopment, neurotoxicity, Environmental pollution, TD172-193.5, Environmental sciences, GE1-350 |
| الوصف: | Deltamethrin (DM) is a highly effective and widely used pyrethroid pesticide. It is an environmental factor affecting public and occupational health and exerts direct toxic effects on the central nervous system. As the major target organs for neurotoxicity of DM, the hippocampus and the cerebellum are critical to the learning and motor function. Pregnant Wistar rats were randomly divided into four groups and gavaged at doses of 0, 1, 4or 10 mg/kg/d DM from gestational day (GD) 0 to postnatal day (PN) 21. The PC12 cells were selected to further verify the regulatory mechanisms of DM on the neurodevelopmental injury. We found that maternal exposure to DM caused learning, memory and motor dysfunction in male offspring. Maternal exposure to DM induced the decrease in the density of hippocampal dendritic spines in male offspring through the reduced expression of M1 mAchRs, which in turn reduced the mediated AKT/mTOR signaling pathway, contributing to the inhibition of dynamic changes of GluA1. Meanwhile, DM exposure inhibited the BDNF/TrkB signaling pathway, thereby reducing phosphorylation of stathmin and impairing cerebellar purkinje cell dendrite growth and development. Taken together, maternal exposure to DM during pregnancy and lactation could impair neurodevelopment of male offspring. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 0147-6513 |
| Relation: | http://www.sciencedirect.com/science/article/pii/S0147651324002720; https://doaj.org/toc/0147-6513 |
| DOI: | 10.1016/j.ecoenv.2024.116196 |
| URL الوصول: | https://doaj.org/article/768d91557b1647dd936eaa36d5263e72 |
| رقم الأكسشن: | edsdoj.768d91557b1647dd936eaa36d5263e72 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 01476513 |
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| DOI: | 10.1016/j.ecoenv.2024.116196 |