دورية أكاديمية
Dual-Activated Nano-Prodrug for Chemo-Photodynamic Combination Therapy of Breast Cancer
| العنوان: | Dual-Activated Nano-Prodrug for Chemo-Photodynamic Combination Therapy of Breast Cancer |
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| المؤلفون: | Ziyao Lu, Gan Xu, Xiaozhen Yang, Shijia Liu, Yang Sun, Li Chen, Qinying Liu, Jianyong Liu |
| المصدر: | International Journal of Molecular Sciences, Vol 23, Iss 24, p 15656 (2022) |
| بيانات النشر: | MDPI AG, 2022. |
| سنة النشر: | 2022 |
| المجموعة: | LCC:Biology (General) LCC:Chemistry |
| مصطلحات موضوعية: | nano-prodrug, photodynamic therapy, reactive oxygen species, activation, combination therapy, Biology (General), QH301-705.5, Chemistry, QD1-999 |
| الوصف: | Herein, we developed a dual-activated prodrug, BTC, that contains three functional components: a glutathione (GSH)-responsive BODIPY-based photosensitizer with a photoinduced electron transfer (PET) effect between BODIPY and the 2,4-dinitrobenzenesulfonate (DNBS) group, and an ROS-responsive thioketal linker connecting BODIPY and the chemotherapeutic agent camptothecin (CPT). Interestingly, CPT displayed low toxicity because the active site of CPT was modified by the BODIPY-based macrocycle. Additionally, BTC was encapsulated with the amphiphilic polymer DSPE-mPEG2000 to improve drug solubility and tumor selectivity. The resulting nano-prodrug passively targeted tumor cells through enhanced permeability and retention (EPR) effects, and then the photosensitizing ability of the BODIPY dye was restored by removing the DNBS group with the high concentration of GSH in tumor cells. Light-triggered ROS from activated BODIPY can not only induce apoptosis or necrosis of tumor cells but also sever the thioketal linker to release CPT, achieving the combination treatment of selective photodynamic therapy and chemotherapy. The antitumor activity of the prodrug has been demonstrated in mouse mammary carcinoma 4T1 and human breast cancer MCF-7 cell lines and 4T1 tumor-bearing mice. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1422-0067 1661-6596 |
| Relation: | https://www.mdpi.com/1422-0067/23/24/15656; https://doaj.org/toc/1661-6596; https://doaj.org/toc/1422-0067 |
| DOI: | 10.3390/ijms232415656 |
| URL الوصول: | https://doaj.org/article/76a92c61cac94cad872321b3bcd9fc58 |
| رقم الأكسشن: | edsdoj.76a92c61cac94cad872321b3bcd9fc58 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 14220067 16616596 |
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| DOI: | 10.3390/ijms232415656 |