دورية أكاديمية
Crystal structure of azilsartan methyl ester ethyl acetate hemisolvate
| العنوان: | Crystal structure of azilsartan methyl ester ethyl acetate hemisolvate |
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| المؤلفون: | Zhengyi Li, Rong Liu, Meilan Zhu, Liang Chen, Xiaoqiang Sun |
| المصدر: | Acta Crystallographica Section E: Crystallographic Communications, Vol 71, Iss 2, Pp o84-o85 (2015) |
| بيانات النشر: | International Union of Crystallography, 2015. |
| سنة النشر: | 2015 |
| المجموعة: | LCC:Crystallography |
| مصطلحات موضوعية: | crystal structure, azilsartan, azilsartan methyl ester, antihypertension, Crystallography, QD901-999 |
| الوصف: | The title compound, C26H22N4O5 (systematic name: methyl 2-ethoxy-1-{4-[2-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)phenyl]benzyl}-1H-1,3-benzodiazole-7-carboxylate ethyl acetate hemisolvate), was obtained via cyclization of methyl (Z)-2-ethoxy-1-{(2′-(N′-hydroxycarbamimidoyl)-[1,1′-biphenyl]-4-yl)methyl}-1H-benzo[d]imidazole-7-carboxylate with diphenyl carbonate. There are two independent molecules (A and B) with different conformations and an ethyl acetate solvent molecule in the asymmetric unit. In molecule A, the dihedral angle between the benzene ring and its attached oxadiazole ring is 59.36 (17); the dihedral angle between the benzene rings is 43.89 (15) and that between the benzene ring and its attached imidazole ring system is 80.06 (11)°. The corresponding dihedral angles in molecule B are 58.45 (18), 50.73 (16) and 85.37 (10)°, respectively. The C—O—C—Cm (m = methyl) torsion angles for the ethoxy side chains attached to the imidazole rings in molecules A and B are 93.9 (3) and −174.6 (3)°, respectively. In the crystal, the components are linked by N—H...N and C—H...O hydrogen bonds, generating a three-dimensional network. Aromatic π–π stacking interactions [shortest centroid–centroid separation = 3.536 (3)Å] are also observed. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2056-9890 20569890 |
| Relation: | http://scripts.iucr.org/cgi-bin/paper?S2056989014028023; https://doaj.org/toc/2056-9890 |
| DOI: | 10.1107/S2056989014028023 |
| URL الوصول: | https://doaj.org/article/a76cb8d6540847918f8416e61cf7e0c4 |
| رقم الأكسشن: | edsdoj.76cb8d6540847918f8416e61cf7e0c4 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 20569890 |
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| DOI: | 10.1107/S2056989014028023 |