دورية أكاديمية
S-nitrosothiols, and other products of nitrate metabolism, are increased in multiple human blood compartments following ingestion of beetroot juice
| العنوان: | S-nitrosothiols, and other products of nitrate metabolism, are increased in multiple human blood compartments following ingestion of beetroot juice |
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| المؤلفون: | Mohammed Abu-Alghayth, Anni Vanhatalo, Lee J. Wylie, Sinead TJ. McDonagh, Christopher Thompson, Stefan Kadach, Paul Kerr, Miranda J. Smallwood, Andrew M. Jones, Paul G. Winyard |
| المصدر: | Redox Biology, Vol 43, Iss , Pp 101974- (2021) |
| بيانات النشر: | Elsevier, 2021. |
| سنة النشر: | 2021 |
| المجموعة: | LCC:Medicine (General) LCC:Biology (General) |
| مصطلحات موضوعية: | Nitrate, Nitrite, S-nitrosothiols (RSNO), Plasma, Red blood cells (RBCs), Beetroot (BR), Medicine (General), R5-920, Biology (General), QH301-705.5 |
| الوصف: | Ingested inorganic nitrate (NO3⁻) has multiple effects in the human body including vasodilation, inhibition of platelet aggregation, and improved skeletal muscle function. The functional effects of oral NO3⁻ involve the in vivo reduction of NO3⁻ to nitrite (NO2⁻) and thence to nitric oxide (NO). However, the potential involvement of S-nitrosothiol (RSNO) formation is unclear. We hypothesised that the RSNO concentration ([RSNO]) in red blood cells (RBCs) and plasma is increased by NO3⁻-rich beetroot juice ingestion. In healthy human volunteers, we tested the effect of dietary supplementation with NO3⁻-rich beetroot juice (BR) or NO3⁻-depleted beetroot juice (placebo; PL) on [RSNO], [NO3⁻] and [NO2⁻] in RBCs, whole blood and plasma, as measured by ozone-based chemiluminescence. The median basal [RSNO] in plasma samples (n = 22) was 10 (5–13) nM (interquartile range in brackets). In comparison, the median values for basal [RSNO] in the corresponding RBC preparations (n = 19) and whole blood samples (n = 19) were higher (p |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2213-2317 |
| Relation: | http://www.sciencedirect.com/science/article/pii/S2213231721001221; https://doaj.org/toc/2213-2317 |
| DOI: | 10.1016/j.redox.2021.101974 |
| URL الوصول: | https://doaj.org/article/ccca76cc967d449a8f90645b4e0a2df6 |
| رقم الأكسشن: | edsdoj.76cc967d449a8f90645b4e0a2df6 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 22132317 |
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| DOI: | 10.1016/j.redox.2021.101974 |