دورية أكاديمية
The Role of Microbiota in Liver Transplantation and Liver Transplantation-Related Biliary Complications
| العنوان: | The Role of Microbiota in Liver Transplantation and Liver Transplantation-Related Biliary Complications |
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| المؤلفون: | Ulrich Wirth, Tianxiao Jiang, Josefine Schardey, Katharina Kratz, Mingming Li, Malte Schirren, Florian Kühn, Alexandr Bazhin, Jens Werner, Markus Guba, Christian Schulz, Joachim Andrassy |
| المصدر: | International Journal of Molecular Sciences, Vol 24, Iss 5, p 4841 (2023) |
| بيانات النشر: | MDPI AG, 2023. |
| سنة النشر: | 2023 |
| المجموعة: | LCC:Biology (General) LCC:Chemistry |
| مصطلحات موضوعية: | liver transplantation, biliary microbiome, biliary complications, multi-drug resistant microbiota, ischemic-type biliary lesions, Biology (General), QH301-705.5, Chemistry, QD1-999 |
| الوصف: | Liver transplantation as a treatment option for end-stage liver diseases is associated with a relevant risk for complications. On the one hand, immunological factors and associated chronic graft rejection are major causes of morbidity and carry an increased risk of mortality due to liver graft failure. On the other hand, infectious complications have a major impact on patient outcomes. In addition, abdominal or pulmonary infections, and biliary complications, including cholangitis, are common complications in patients after liver transplantation and can also be associated with a risk for mortality. Thereby, these patients already suffer from gut dysbiosis at the time of liver transplantation due to their severe underlying disease, causing end-stage liver failure. Despite an impaired gut-liver axis, repeated antibiotic therapies can cause major changes in the gut microbiome. Due to repeated biliary interventions, the biliary tract is often colonized by several bacteria with a high risk for multi-drug resistant germs causing local and systemic infections before and after liver transplantation. Growing evidence about the role of gut microbiota in the perioperative course and their impact on patient outcomes in liver transplantation is available. However, data about biliary microbiota and their impact on infectious and biliary complications are still sparse. In this comprehensive review, we compile the current evidence for the role of microbiome research in liver transplantation with a focus on biliary complications and infections due to multi-drug resistant germs. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1422-0067 1661-6596 |
| Relation: | https://www.mdpi.com/1422-0067/24/5/4841; https://doaj.org/toc/1661-6596; https://doaj.org/toc/1422-0067 |
| DOI: | 10.3390/ijms24054841 |
| URL الوصول: | https://doaj.org/article/e7766ad125e64c15bc8e0499fe15c186 |
| رقم الأكسشن: | edsdoj.7766ad125e64c15bc8e0499fe15c186 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 14220067 16616596 |
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| DOI: | 10.3390/ijms24054841 |