دورية أكاديمية

AKAP150 from nucleus accumbens dopamine D1 and D2 receptor-expressing medium spiny neurons regulates morphine withdrawal

التفاصيل البيبلوغرافية
العنوان: AKAP150 from nucleus accumbens dopamine D1 and D2 receptor-expressing medium spiny neurons regulates morphine withdrawal
المؤلفون: Xiaohui Bai, Kun Zhang, Chaopeng Ou, Yanyu Mu, Dongmei Chi, Jianxing Zhang, Jingxiu Huang, Xile Li, Yingjun Zhang, Wan Huang, Handong Ouyang
المصدر: iScience, Vol 26, Iss 11, Pp 108227- (2023)
بيانات النشر: Elsevier, 2023.
سنة النشر: 2023
المجموعة: LCC:Science
مصطلحات موضوعية: Natural sciences, Biological sciences, Neuroscience, Behavioral neuroscience, Systems neuroscience, Science
الوصف: Summary: Dopamine D1 receptor-expressing medium spiny neurons (D1R-MSNs) and dopamine D2 receptor-expressing MSNs (D2R-MSNs) in nucleus accumbens (NAc) have been demonstrated to show different effects on reward and memory of abstinence. A-kinase anchoring protein 150 (AKAP150) expression in NAc is significantly upregulated and contributes to the morphine withdrawal behavior. However, the underlying mechanism of AKAP150 under opioid withdrawal remains unclear. In this study, AKAP150 expression in NAc is upregulated in naloxone-precipitated morphine withdrawal model, and knockdown of AKAP150 alleviates morphine withdrawal somatic signs and improves the performance of conditioned place aversion (CPA) test. AKAP150 in NAc D1R-MSNs is related to modulation of the performance of morphine withdrawal CPA test, while AKAP150 in NAc D2R-MSNs is relevant to the severity of somatic responses. Our results suggest that AKAP150 from D1R-MSNs or D2R-MSNs in NAc contributes to the developmental process of morphine withdrawal but plays different roles in aspects of behavior or psychology.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 2589-0042
Relation: http://www.sciencedirect.com/science/article/pii/S2589004223023040; https://doaj.org/toc/2589-0042
DOI: 10.1016/j.isci.2023.108227
URL الوصول: https://doaj.org/article/c778d59767e74558bf88faae0a73a92e
رقم الأكسشن: edsdoj.778d59767e74558bf88faae0a73a92e
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:25890042
DOI:10.1016/j.isci.2023.108227