دورية أكاديمية

Combining multiomics to analyze the molecular mechanism of hair follicle cycle change in cashmere goats from Inner Mongolia

التفاصيل البيبلوغرافية
العنوان: Combining multiomics to analyze the molecular mechanism of hair follicle cycle change in cashmere goats from Inner Mongolia
المؤلفون: Chongyan Zhang, Qing Qin, Zhichen Liu, Yichuan Wang, Mingxi Lan, Dan Zhao, Jingwen Zhang, Zhixin Wang, Jinquan Li, Zhihong Liu
المصدر: Frontiers in Veterinary Science, Vol 11 (2024)
بيانات النشر: Frontiers Media S.A., 2024.
سنة النشر: 2024
المجموعة: LCC:Veterinary medicine
مصطلحات موضوعية: apoptosis, ribosomal protein, hair follicle, telogen, anagen, catagen, Veterinary medicine, SF600-1100
الوصف: Sheep body size can directly reflect the growth rates and fattening rates of sheep and is also an important index for measuring the growth performance of meat sheep.Inner Mongolia Cashmere Goat is a local excellent breed of cashmere and meat dual-purpose, which is a typical heterogeneous indumentum. The hair follicles cycle through periods of vigorous growth (anagen), a regression caused by apoptosis (catagen), and relative rest (telogen). At present, it is not clear which genes affect the cycle transformation of hair follicles and unclear how proteins impact the creation and expansion of hair follicles.we using multi-omics joint analysis methodologies to investigated the possible pathways of transformation and apoptosis in goat hair follicles. The results showed that 917,1,187, and 716 proteins were specifically expressed in anagen, catagen andtelogen. The result of gene ontology (GO) annotation showed that differentially expressed proteins (DEPs) are in different growth cycle periods, and enriched GO items are mostly related to the transformation of cells and proteins. The Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment result indicated that the apoptosis process has a great impact on hair follicle’s growth cycle. The results of the protein interaction network of differential proteins showed that the ribosomal protein family (RPL4, RPL8, RPS16, RPS18, RPS2, RPS27A, RPS3) was the core protein in the network. The results of combined transcriptome and proteomics analysis showed that there were 16,34, and 26 overlapped DEGs and DEPs in the comparison of anagen VS catagen, catagen VS telogen and anagen VS telogen, of which API5 plays an important role in regulating protein and gene expression levels. We focused on API5 and Ribosomal protein and found that API5 affected the apoptosis process of hair follicles, and ribosomal protein was highly expressed in the resting stage of hair follicles. They are both useful as molecular marker candidate genes to study hair follicle growth and apoptosis,and they both have an essential function in the cycle transition process of hair follicles. The results of this study may provide a theoretical basis for further research on the growth and development of hair follicles in Inner Mongolian Cashmere goats.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 2297-1769
Relation: https://www.frontiersin.org/articles/10.3389/fvets.2024.1405355/full; https://doaj.org/toc/2297-1769
DOI: 10.3389/fvets.2024.1405355
URL الوصول: https://doaj.org/article/77aad281b8884c86b608f98dafad2bd0
رقم الأكسشن: edsdoj.77aad281b8884c86b608f98dafad2bd0
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:22971769
DOI:10.3389/fvets.2024.1405355