دورية أكاديمية
Hashimoto's thyroiditis attenuates progression of papillary thyroid carcinoma: deciphering immunological links
| العنوان: | Hashimoto's thyroiditis attenuates progression of papillary thyroid carcinoma: deciphering immunological links |
|---|---|
| المؤلفون: | Oksana Sulaieva, Oleksii Selezniov, Dmytro Shapochka, Nataliia Belemets, Oleksandr Nechay, Yelizaveta Chereshneva, Dibakhan Tsomartova, Marina Ivanova |
| المصدر: | Heliyon, Vol 6, Iss 1, Pp e03077- (2020) |
| بيانات النشر: | Elsevier, 2020. |
| سنة النشر: | 2020 |
| المجموعة: | LCC:Science (General) LCC:Social sciences (General) |
| مصطلحات موضوعية: | Immunology, Cancer research, Endocrinology, Pathology, Thyroid cancer, Hashimoto's thyroiditis, Science (General), Q1-390, Social sciences (General), H1-99 |
| الوصف: | Although some studies have investigated the clinicopathologic relationships between papillary thyroid carcinoma (PTC) and Hashimoto's thyroiditis (HT), there is still no clear understanding of differences in tumor immune microenvironment for PTC with coexisting HT and HT effect on PTC progression. The aim of this study was to clarify immune-mediated mechanisms of coexisting HT, which might influence PTC progression. 30 patients with histologically confirmed conventional-type PTC and 30 patients with PTC and coexisting HT were enrolled in the study. To analyze the role of immune-mediated links between PTC and HT, immunohistochemical investigation was conducted to count the number of different immune cells including T-cytotoxic cells (CD8), plasma cells (CD138), Treg cells (FOXP3), mast cells (MCT), and M2 macrophages (CD163). It was shown that despite the high number of immune cells in the intact thyroid tissues of PTC patients with coexisting HT there were no significant differences in M2 macrophages, mast cells and Treg counts inside PTC with or without HT. PTC with HT was associated with a higher number of CD8+ cells (P < 0.001) reflecting the ability of immune system to generate and recruit T-cytotoxic cells in tumor area, which can explain the protective effect of HT on PTC progression. Lymph node metastases development was associated with an increased number of mast cells, M2 macrophages and Treg along with a decreased plasma cells count regardless of coexisting HT. However, we did not find significant differences in T-cytotoxic cells quantity in node-positive and node-negative patients with or without HT, which encourages further investigation of immune escape mechanisms in PTC. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2405-8440 99754118 |
| Relation: | http://www.sciencedirect.com/science/article/pii/S2405844019367362; https://doaj.org/toc/2405-8440 |
| DOI: | 10.1016/j.heliyon.2019.e03077 |
| URL الوصول: | https://doaj.org/article/77d7737a99754118aec19d1f9313285e |
| رقم الأكسشن: | edsdoj.77d7737a99754118aec19d1f9313285e |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 24058440 99754118 |
|---|---|
| DOI: | 10.1016/j.heliyon.2019.e03077 |