دورية أكاديمية
Occipital atrophy signature in prodromal Lewy bodies disease
| العنوان: | Occipital atrophy signature in prodromal Lewy bodies disease |
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| المؤلفون: | Alice Galli, Andrea Pilotto, Benedetta Chiarini, Marcello Giunta, Daniele Corbo, Clara Tirloni, Daniel Ferreira, Enrico Premi, Alessandro Lupini, Cinzia Zatti, Laura Bonanni, Pietro Tiraboschi, Roberto Gasparotti, Alessandro Padovani |
| المصدر: | Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, Vol 15, Iss 4, Pp n/a-n/a (2023) |
| بيانات النشر: | Wiley, 2023. |
| سنة النشر: | 2023 |
| المجموعة: | LCC:Neurology. Diseases of the nervous system LCC:Geriatrics |
| مصطلحات موضوعية: | cortical thickness, MRI, occipital atrophy, prodromal DLB, voxel‐based morphometry, Neurology. Diseases of the nervous system, RC346-429, Geriatrics, RC952-954.6 |
| الوصف: | Abstract INTRODUCTION Dementia with Lewy bodies (DLB) is typically characterized by parietal, temporal, and occipital atrophy, but less is known about the newly defined prodromal phases. The objective of this study was to evaluate structural brain alterations in prodromal DLB (p‐DLB) as compared to healthy controls (HC) and full‐blown dementia (DLB‐DEM). METHODS The study included 42 DLB patients (n = 20 p‐DLB; n = 22 DLB‐DEM) and 27 HC with a standardized neurological assessment and 3‐tesla magnetic resonance imaging. Voxel‐wise analyses on gray‐matter and cortical thickness were implemented to evaluate differences between p‐DLB, DLB‐DEM, and HC. RESULTS p‐DLB and DLB‐DEM exhibited reduced occipital and posterior parieto‐temporal volume and thickness, extending from prodromal to dementia stages. Occipital atrophy was more sensitive than insular atrophy in differentiating p‐DLB and HC. Occipital atrophy correlated to frontotemporal structural damage increasing from p‐DLB to DLB‐DEM. DISCUSSION Occipital and posterior‐temporal structural alterations are an early signature of the DLB continuum and correlate with a long‐distance pattern of atrophy. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2352-8729 |
| Relation: | https://doaj.org/toc/2352-8729 |
| DOI: | 10.1002/dad2.12462 |
| URL الوصول: | https://doaj.org/article/780e015bfd104261aa1625b9fdf62edf |
| رقم الأكسشن: | edsdoj.780e015bfd104261aa1625b9fdf62edf |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 23528729 |
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| DOI: | 10.1002/dad2.12462 |