دورية أكاديمية
High Pathogenicity of Nipah Virus from Pteropus lylei Fruit Bats, Cambodia
| العنوان: | High Pathogenicity of Nipah Virus from Pteropus lylei Fruit Bats, Cambodia |
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| المؤلفون: | Maria Gaudino, Noémie Aurine, Claire Dumont, Julien Fouret, Marion Ferren, Cyrille Mathieu, Olivier Reynard, Viktor E. Volchkov, Catherine Legras-Lachuer, Marie-Claude Georges-Courbot, Branka Horvat |
| المصدر: | Emerging Infectious Diseases, Vol 26, Iss 1, Pp 104-113 (2020) |
| بيانات النشر: | Centers for Disease Control and Prevention, 2020. |
| سنة النشر: | 2020 |
| المجموعة: | LCC:Medicine LCC:Infectious and parasitic diseases |
| مصطلحات موضوعية: | Nipah virus, henipavirus, emerging infection, Pteropus bats, fruit bats, spillover, Medicine, Infectious and parasitic diseases, RC109-216 |
| الوصف: | We conducted an in-depth characterization of the Nipah virus (NiV) isolate previously obtained from a Pteropus lylei bat in Cambodia in 2003 (CSUR381). We performed full-genome sequencing and phylogenetic analyses and confirmed CSUR381 is part of the NiV-Malaysia genotype. In vitro studies revealed similar cell permissiveness and replication of CSUR381 (compared with 2 other NiV isolates) in both bat and human cell lines. Sequence alignments indicated conservation of the ephrin-B2 and ephrin-B3 receptor binding sites, the glycosylation site on the G attachment protein, as well as the editing site in phosphoprotein, suggesting production of nonstructural proteins V and W, known to counteract the host innate immunity. In the hamster animal model, CSUR381 induced lethal infections. Altogether, these data suggest that the Cambodia bat-derived NiV isolate has high pathogenic potential and, thus, provide insight for further studies and better risk assessment for future NiV outbreaks in Southeast Asia. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1080-6040 1080-6059 |
| Relation: | https://wwwnc.cdc.gov/eid/article/26/1/19-1284_article; https://doaj.org/toc/1080-6040; https://doaj.org/toc/1080-6059 |
| DOI: | 10.3201/eid2601.191284 |
| URL الوصول: | https://doaj.org/article/780e491767f84adc892fd6b97472f2a9 |
| رقم الأكسشن: | edsdoj.780e491767f84adc892fd6b97472f2a9 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 10806040 10806059 |
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| DOI: | 10.3201/eid2601.191284 |