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Association between physical activity and digestive-system cancer: An updated systematic review and meta-analysis

التفاصيل البيبلوغرافية
العنوان: Association between physical activity and digestive-system cancer: An updated systematic review and meta-analysis
المؤلفون: Fangfang Xie, Yanli You, Jihan Huang, Chong Guan, Ziji Chen, Min Fang, Fei Yao, Jia Han
المصدر: Journal of Sport and Health Science, Vol 10, Iss 1, Pp 4-13 (2021)
بيانات النشر: Elsevier, 2021.
سنة النشر: 2021
المجموعة: LCC:Sports
LCC:Sports medicine
مصطلحات موضوعية: Digestive-system cancer, Meta-analysis, Physical activity, Sports, GV557-1198.995, Sports medicine, RC1200-1245
الوصف: Background: Physical activity (PA) may have an impact on digestive-system cancer (DSC) by improving insulin sensitivity and anticancer immune function and by reducing the exposure of the digestive tract to carcinogens by stimulating gastrointestinal motility, thus reducing transit time. The current study aimed to determine the effect of PA on different types of DSC via a systematic review and meta-analysis. Methods: In accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, we searched for relevant studies in PubMed, Embase, Web of Science, Cochrane Library, and China National Knowledge Infrastructure. Using a random effects model, the relationship between PA and different types of DSC was analyzed. Results: The data used for meta-analysis were derived from 161 risk estimates in 47 studies involving 5,797,768 participants and 55,162 cases. We assessed the pooled associations between high vs. low PA levels and the risk of DSC (risk ratio (RR) = 0.82, 95% confidence interval (95%CI): 0.79–0.85), colon cancer (RR = 0.81, 95%CI: 0.76–0.87), rectal cancer (RR = 0.88, 95%CI: 0.80–0.98), colorectal cancer (RR = 0.77, 95%CI: 0.69–0.85), gallbladder cancer (RR = 0.79, 95%CI: 0.64–0.98), gastric cancer (RR = 0.83, 95%CI: 0.76–0.91), liver cancer (RR = 0.73, 0.60–0.89), oropharyngeal cancer (RR = 0.79, 95%CI: 0.72–0.87), and pancreatic cancer (RR = 0.85, 95%CI: 0.78–0.93). The findings were comparable between case-control studies (RR = 0.73, 95%CI: 0.68–0.78) and prospective cohort studies (RR = 0.88, 95%CI: 0.80–0.91). The meta-analysis of 9 studies reporting low, moderate, and high PA levels, with 17 risk estimates, showed that compared to low PA, moderate PA may also reduce the risk of DSC (RR = 0.89, 95%CI: 0.80–1.00), while compared to moderate PA, high PA seemed to slightly increase the risk of DSC, although the results were not statistically significant (RR = 1.11, 95%CI: 0.94–1.32). In addition, limited evidence from 5 studies suggested that meeting the international PA guidelines might not significantly reduce the risk of DSC (RR = 0.96, 95%CI: 0.91–1.02). Conclusion: Compared to previous research, this systematic review has provided more comprehensive information about the inverse relationship between PA and DSC risk. The updated evidence from the current meta-analysis indicates that a moderate-to-high PA level is a common protective factor that can significantly lower the overall risk of DSC. However, the reduction rate for specific cancers may vary. In addition, limited evidence suggests that meeting the international PA guidelines might not significantly reduce the risk of DSC. Thus, future studies must be conducted to determine the optimal dosage, frequency, intensity, and duration of PA required to reduce DSC risk effectively.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 2095-2546
Relation: http://www.sciencedirect.com/science/article/pii/S2095254620301289; https://doaj.org/toc/2095-2546
DOI: 10.1016/j.jshs.2020.09.009
URL الوصول: https://doaj.org/article/786b7c3102e845498faa049a719a0546
رقم الأكسشن: edsdoj.786b7c3102e845498faa049a719a0546
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:20952546
DOI:10.1016/j.jshs.2020.09.009