دورية أكاديمية
Fabrication of Artificial Nerve Conduits Used in a Long Nerve Gap: Current Reviews and Future Studies
| العنوان: | Fabrication of Artificial Nerve Conduits Used in a Long Nerve Gap: Current Reviews and Future Studies |
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| المؤلفون: | Ryosuke Kakinoki, Yukiko Hara, Koichi Yoshimoto, Yukitoshi Kaizawa, Kazuhiko Hashimoto, Hiroki Tanaka, Takaya Kobayashi, Kazuhiro Ohtani, Takashi Noguchi, Ryosuke Ikeguchi, Masao Akagi, Koji Goto |
| المصدر: | Bioengineering, Vol 11, Iss 4, p 409 (2024) |
| بيانات النشر: | MDPI AG, 2024. |
| سنة النشر: | 2024 |
| المجموعة: | LCC:Technology LCC:Biology (General) |
| مصطلحات موضوعية: | artificial nerve, vascularity, fibrin matrix, scaffolds, stem cells, Technology, Biology (General), QH301-705.5 |
| الوصف: | There are many commercially available artificial nerve conduits, used mostly to repair short gaps in sensory nerves. The stages of nerve regeneration in a nerve conduit are fibrin matrix formation between the nerve stumps joined to the conduit, capillary extension and Schwann cell migration from both nerve stumps, and, finally, axon extension from the proximal nerve stump. Artificial nerves connecting transected nerve stumps with a long interstump gap should be biodegradable, soft and pliable; have the ability to maintain an intrachamber fibrin matrix structure that allows capillary invasion of the tubular lumen, inhibition of scar tissue invasion and leakage of intratubular neurochemical factors from the chamber; and be able to accommodate cells that produce neurochemical factors that promote nerve regeneration. Here, we describe current progress in the development of artificial nerve conduits and the future studies needed to create nerve conduits, the nerve regeneration of which is compatible with that of an autologous nerve graft transplanted over a long nerve gap. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2306-5354 |
| Relation: | https://www.mdpi.com/2306-5354/11/4/409; https://doaj.org/toc/2306-5354 |
| DOI: | 10.3390/bioengineering11040409 |
| URL الوصول: | https://doaj.org/article/78adace4e4584f678e6fc93e8024a334 |
| رقم الأكسشن: | edsdoj.78adace4e4584f678e6fc93e8024a334 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 23065354 |
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| DOI: | 10.3390/bioengineering11040409 |