دورية أكاديمية
Influence of correction of nutritive deficiency on the effectiveness of neoadjuvant chemotherapy in patients with locally advanced gastric cancer
| العنوان: | Influence of correction of nutritive deficiency on the effectiveness of neoadjuvant chemotherapy in patients with locally advanced gastric cancer |
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| المؤلفون: | Nadezhda A. Brish, Tatiana Yu. Semiglazova, Aleksei M. Karachun, Lev N. Shevkunov, Yana A. Ulyanchenko, Anna S. Artemyeva, Tatiana S. Golovanova, Elena V. Tkachenko, Yuliia V. Alexeeva, Sofiko M. Sharashenidze, Liubov V. Strakh, Svetlana A. Protsenko, Gulfiia M. Teletaeva, Larisa V. Filatova, Boris S. Kasparov, Vladislav V. Semiglazov, Aleksei M. Belyaev |
| المصدر: | Современная онкология, Vol 23, Iss 3, Pp 519-524 (2021) |
| بيانات النشر: | IP Habib O.N., 2021. |
| سنة النشر: | 2021 |
| المجموعة: | LCC:Neoplasms. Tumors. Oncology. Including cancer and carcinogens |
| مصطلحات موضوعية: | locally advanced gastric cancer, nutritional status, nutritional deficiency, neoadjuvant chemotherapy, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282 |
| الوصف: | Aim. To increase the effectiveness of neoadjuvant chemotherapy in patients with locally advanced gastric cancer by correcting nutritional deficiency. Materials and methods. Of 200 patients with locally advanced gastric cancer (mean age 57.2 years (46.168.3), 100 patients received neoadjuvant chemotherapy with nutritional support from 2018 to 2020. One hundred patients received neoadjuvant chemotherapy without nutritional support from 2013 to 2018 (historical control). The incidence of nutritional deficiency before treatment in the neoadjuvant chemotherapy + nutritional support group was 54%, and in the neoadjuvant chemotherapy only group it was 47%. Nutritional status was assessed using anthropometry, questionnaires (NRS-2002, MUST, GLIM), dynamometry, blood tests, bioimpedance. Complications according to NCI CTCAE v5.0; оbjective response rate according to RECIST 1.1; pathomorphological regression according to the JGCA classification (2017); 2-year event-free survival were assessed. Results. The frequency of nutritional deficiency before the start of treatment in the neoadjuvant chemotherapy + nutritional support group was 54%, in the neoadjuvant chemotherapy only group 47%. After the completion of neoadjuvant chemotherapy in the group neoadjuvant chemotherapy + nutritional support the frequency of nutritional deficiency was 1%, in the group neoadjuvant chemotherapy only without nutritional support 62%. In patients with nutritional deficiency in the neoadjuvant chemotherapy + nutritional support group, partial regression was registered in 51.9% of cases, in the neoadjuvant chemotherapy only group it was 27.6% (p0.05). There were no differences in the frequency of pathological response. 2-year event-free survival in patients without nutritional deficiency in the group neoadjuvant chemotherapy + nutritional support was 100%, in the neoadjuvant chemotherapy only group it was 68.5% (p0.001); in patients with nutritional deficiency 72,5 and 60.6% respectively (p0.05). Conclusion. Nutritional deficiency is an important predictive and prognostic marker of the efficacy of neoadjuvant chemotherapy in the treatment of locally advanced gastric cancer. Comprehensive diagnosis of nutritional status and nutritional support can improve the results of neoadjuvant chemotherapy in patients with locally advanced gastric cancer. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | Russian |
| تدمد: | 1815-1434 1815-1442 18151434 |
| Relation: | https://modernonco.orscience.ru/1815-1434/article/viewFile/75939/pdf; https://doaj.org/toc/1815-1434; https://doaj.org/toc/1815-1442 |
| DOI: | 10.26442/18151434.2021.3.201075 |
| URL الوصول: | https://doaj.org/article/78b3375c172c4f1da73dbc63c0963807 |
| رقم الأكسشن: | edsdoj.78b3375c172c4f1da73dbc63c0963807 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 18151434 18151442 |
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| DOI: | 10.26442/18151434.2021.3.201075 |