التفاصيل البيبلوغرافية
العنوان:
STAT1 potentiates oxidative stress revealing a targetable vulnerability that increases phenformin efficacy in breast cancer
المؤلفون:
Stephanie P. Totten , Young Kyuen Im , Eduardo Cepeda Cañedo , Ouafa Najyb , Alice Nguyen , Steven Hébert , Ryuhjin Ahn , Kyle Lewis , Benjamin Lebeau , Rachel La Selva , Valérie Sabourin , Constanza Martínez , Paul Savage , Hellen Kuasne , Daina Avizonis , Nancy Santos Martínez , Catherine Chabot , Adriana Aguilar-Mahecha , Marie-Line Goulet , Matthew Dankner , Michael Witcher , Kevin Petrecca , Mark Basik , Michael Pollak , Ivan Topisirovic , Rongtuan Lin , Peter M. Siegel , Claudia L. Kleinman , Morag Park , Julie St-Pierre , Josie Ursini-Siegel
المصدر:
Nature Communications, Vol 12, Iss 1, Pp 1-20 (2021)
بيانات النشر:
Nature Portfolio, 2021.
سنة النشر:
2021
المجموعة:
LCC:Science
مصطلحات موضوعية:
Science
الوصف:
Complex I inhibition induces oxidative stress leading to cancer cell cytotoxicity. Here, the authors show, in breast cancer models, that inflammatory mediators can potentiate complex I inhibitor phenformin cytotoxicity through STAT1-mediated downregulation of the reactive oxygen species scavenger NQO1.
نوع الوثيقة:
article
وصف الملف:
electronic resource
اللغة:
English
تدمد:
2041-1723
Relation:
https://doaj.org/toc/2041-1723
DOI:
10.1038/s41467-021-23396-2
URL الوصول:
https://doaj.org/article/e78e979f7f9a43d280222791ea6273df
رقم الأكسشن:
edsdoj.78e979f7f9a43d280222791ea6273df
قاعدة البيانات:
Directory of Open Access Journals
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