دورية أكاديمية
The land-scape of immune response to monkeypox virus
| العنوان: | The land-scape of immune response to monkeypox virus |
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| المؤلفون: | Heng Li, Qi-Zhao Huang, Hong Zhang, Zhen-Xing Liu, Xiao-Hui Chen, Li-Lin Ye, Yang Luo |
| المصدر: | EBioMedicine, Vol 87, Iss , Pp 104424- (2023) |
| بيانات النشر: | Elsevier, 2023. |
| سنة النشر: | 2023 |
| المجموعة: | LCC:Medicine LCC:Medicine (General) |
| مصطلحات موضوعية: | Monkeypox, Immunotherapeutic strategies, Zoonotic disease, Immunopathology, Immunopathogenesis, Medicine, Medicine (General), R5-920 |
| الوصف: | Summary: Human monkeypox is a viral zoonotic smallpox-like disease caused by the monkeypox virus (MPXV) and has become the greatest public health threat in the genus Orthopoxvirus after smallpox was eradicated. The host immune response to MPXV plays an essential role in disease pathogenesis and clinical manifestations. MPXV infection leads to skin lesions with the genital area as the main feature in the current outbreak and triggers a strong immune response that results in sepsis, deep tissue abscess, severe respiratory disease, and injuries to multiple immune organs. Emerging evidence shows that the immunopathogenesis of MPXV infection is closely associated with impaired NK-cell function, lymphopenia, immune evasion, increased antibodies, increased blood monocytes and granulocytes, cytokine storm, inhibition of the host complement system, and antibody-dependent enhancement. In this overview, we discuss the immunopathology and immunopathogenesis of monkeypox to aid the development of novel immunotherapeutic strategies against monkeypox. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2352-3964 |
| Relation: | http://www.sciencedirect.com/science/article/pii/S2352396422006065; https://doaj.org/toc/2352-3964 |
| DOI: | 10.1016/j.ebiom.2022.104424 |
| URL الوصول: | https://doaj.org/article/79071992ccef487a80597be0c401db08 |
| رقم الأكسشن: | edsdoj.79071992ccef487a80597be0c401db08 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text via ClinicalKey 
Full Text Finder | تدمد: | 23523964 |
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| DOI: | 10.1016/j.ebiom.2022.104424 |