دورية أكاديمية
Prophylactic Administration of Surfactant in Extremely Premature Infants
| العنوان: | Prophylactic Administration of Surfactant in Extremely Premature Infants |
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| المؤلفون: | Lutz Koch, David Frommhold, Bernd Beedgen, Peter Ruef, Johannes Poeschl |
| المصدر: | Critical Care Research and Practice, Vol 2010 (2010) |
| بيانات النشر: | Hindawi Limited, 2010. |
| سنة النشر: | 2010 |
| المجموعة: | LCC:Medical emergencies. Critical care. Intensive care. First aid |
| مصطلحات موضوعية: | Medical emergencies. Critical care. Intensive care. First aid, RC86-88.9 |
| الوصف: | Objective. To investigate whether prophylactic surfactant administration is superior over selective treatment in preterm infants with respiratory distress syndrome (RDS). Methods. In our retrospective analysis, we compared premature infants (23 + 0 to 26 + 6 weeks) receiving 200 mg/kg surfactant (curosurf0𝑥000𝑎𝑒) within five minutes after birth (prophylactic group, 𝑁=31) with those infants who received surfactant therapy for established RDS (selective group, 𝑁=34). Results. Prophylactic therapy significantly decreased the need for mechanical ventilation (74 hours per patient versus 171 hours per patient, resp.). We observed a reduced incidence of interstitial emphysema (0% versus 9%, resp.), pneumothoraces (3% versus 9%, resp.), chronic lung disease (26% versus 38%, resp.), and surfactant doses per patient (1.3 versus 1.8, resp.), although those variables did not reach significance. Conclusion. We conclude that infants under 27 weeks' gestation profit from prophylactic surfactant administration by reducing the time of mechanical ventilation. This in turn could contribute to reduce the risk for mechanical ventilation associated complications, without any detrimental short-term side effects. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2090-1305 2090-1313 |
| Relation: | https://doaj.org/toc/2090-1305; https://doaj.org/toc/2090-1313 |
| DOI: | 10.1155/2010/235894 |
| URL الوصول: | https://doaj.org/article/7916aed201b64e73a0d5cfd7367b5eed |
| رقم الأكسشن: | edsdoj.7916aed201b64e73a0d5cfd7367b5eed |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 20901305 20901313 |
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| DOI: | 10.1155/2010/235894 |