دورية أكاديمية
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Intercellular Communication between Hepatic Cells in Liver Diseases

التفاصيل البيبلوغرافية
العنوان: Intercellular Communication between Hepatic Cells in Liver Diseases
المؤلفون: Keisaku Sato, Lindsey Kennedy, Suthat Liangpunsakul, Praveen Kusumanchi, Zhihong Yang, Fanyin Meng, Shannon Glaser, Heather Francis, Gianfranco Alpini
المصدر: International Journal of Molecular Sciences, Vol 20, Iss 9, p 2180 (2019)
بيانات النشر: MDPI AG, 2019.
سنة النشر: 2019
المجموعة: LCC:Biology (General)
LCC:Chemistry
مصطلحات موضوعية: liver fibrosis, extracellular vesicles, hepatocytes, macrophages, Biology (General), QH301-705.5, Chemistry, QD1-999
الوصف: Liver diseases are perpetuated by the orchestration of hepatocytes and other hepatic non-parenchymal cells. These cells communicate and regulate with each other by secreting mediators such as peptides, hormones, and cytokines. Extracellular vesicles (EVs), small particles secreted from cells, contain proteins, DNAs, and RNAs as cargos. EVs have attracted recent research interests since they can communicate information from donor cells to recipient cells thereby regulating physiological events via delivering of specific cargo mediators. Previous studies have demonstrated that liver cells secrete elevated numbers of EVs during diseased conditions, and those EVs are internalized into other liver cells inducing disease-related reactions such as inflammation, angiogenesis, and fibrogenesis. Reactions in recipient cells are caused by proteins and RNAs carried in disease-derived EVs. This review summarizes cell-to-cell communication especially via EVs in the pathogenesis of liver diseases and their potential as a novel therapeutic target.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 1422-0067
20092180
Relation: https://www.mdpi.com/1422-0067/20/9/2180; https://doaj.org/toc/1422-0067
DOI: 10.3390/ijms20092180
URL الوصول: https://doaj.org/article/792b64b236cc4a21bb306e677f7d8a81
رقم الأكسشن: edsdoj.792b64b236cc4a21bb306e677f7d8a81
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:14220067
20092180
DOI:10.3390/ijms20092180