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Synthesis of Water-Soluble Iridium (III)-Containing Nanoparticles for Biological Applications

التفاصيل البيبلوغرافية
العنوان: Synthesis of Water-Soluble Iridium (III)-Containing Nanoparticles for Biological Applications
المؤلفون: Huanzhi Hou, Pengfei Sun, Quli Fan, Xiaomei Lu, Cheng Xue, Yixue Zhang, Sichao Tian, Wei Huang
المصدر: Journal of Chemistry, Vol 2015 (2015)
بيانات النشر: Wiley, 2015.
سنة النشر: 2015
المجموعة: LCC:Chemistry
مصطلحات موضوعية: Chemistry, QD1-999
الوصف: Water-soluble nanoparticles (Ir/PGlc-NP, Ir/β-1,3-glucan-NP) based on water-soluble glycopolymers (PGlc), β-1,3-glucan polysaccharide, and conjugated phosphorescent Ir (III) complexes were successfully synthesized by self-assembly. The obtained nanoparticles have good spherical morphological characterization with a mean diameter of 50 nm measured by TEM. Ir/PGlc-NP and Ir/β-1,3-glucan-NP showed the same emission maxima at 565 nm in aqueous solution and both caused effective apoptosis and death of HepG2 and Hela cells after being irradiated at 445 nm for 30 min in vitro. Fluorescence cellular imaging was conducted by confocal laser scanning microscopy (CLSM) using HepG2 cells as the model cell in which the nanoparticles had successfully entered into the cytoplasm with high brightness. Furthermore, after injecting the nanoparticles into live mice in vivo, the real-time fluorescence imaging as well as the nanoparticles distribution in organs at 24 hours after administration indicated that these nanoparticles can serve as fluorescent imaging contrast for further biological applications.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 2090-9063
2090-9071
Relation: https://doaj.org/toc/2090-9063; https://doaj.org/toc/2090-9071
DOI: 10.1155/2015/475602
URL الوصول: https://doaj.org/article/d79332ddd1eb403eab40a32e272eda80
رقم الأكسشن: edsdoj.79332ddd1eb403eab40a32e272eda80
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:20909063
20909071
DOI:10.1155/2015/475602