دورية أكاديمية
The Chemical Compounds of Flacourtia rukam Leaves and Their Inhibition of Angiotensin-converting Enzyme (ACE) Activity
| العنوان: | The Chemical Compounds of Flacourtia rukam Leaves and Their Inhibition of Angiotensin-converting Enzyme (ACE) Activity |
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| المؤلفون: | Muharni Muharni, Heni Yohandini, Elfita Elfita, Fitrya Fitrya, Ani Sarah, Rifdah Nabila |
| المصدر: | Molekul, Vol 16, Iss 3, Pp 217-223 (2021) |
| بيانات النشر: | Jenderal Soedirman University, 2021. |
| سنة النشر: | 2021 |
| المجموعة: | LCC:Chemistry |
| مصطلحات موضوعية: | Chemistry, QD1-999 |
| الوصف: | Flacourtia rukam is a plant popular among people to treat hypertension, especially the Musi Banyuasin of south Sumatera, Indonesia. Isolation and identification of chemical compounds from F. rukam leaves and evaluation of their effects on antihypertensive activity have been conducted. Isolation of chemical compounds using chromatographic methods and identification using spectroscopic methods were compared with the reported data. The drug’s effects on antihypertension were determined using the angiotensin converting enzyme (ACE) inhibitory method. Two compounds were first reported and isolated from the leaves of F. rukam and identified as apigenin (1) and lupeol (2). These compounds were demonstrated to be effective in treating antihypertension with IC50 656.51 ± 1.55 µg/mL for apigenin and 15.12 ± 0.72 µg/mL for lupeol. It can be concluded that F. rukam leaves is a potential ACE inhibitor can be explored further as an effective antihypertensive agent. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English Indonesian |
| تدمد: | 1907-9761 2503-0310 |
| Relation: | https://ojs.jmolekul.com/ojs/index.php/jm/article/view/799; https://doaj.org/toc/1907-9761; https://doaj.org/toc/2503-0310 |
| DOI: | 10.20884/1.jm.2021.16.3.799 |
| URL الوصول: | https://doaj.org/article/7960cf329b8c46188c3f34134c89d612 |
| رقم الأكسشن: | edsdoj.7960cf329b8c46188c3f34134c89d612 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 19079761 25030310 |
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| DOI: | 10.20884/1.jm.2021.16.3.799 |